Genetic variations in the vitamin-D receptor (VDR) gene in preeclampsia patients in the Chinese Han population

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Ying ZhanXuemei Liu

Abstract

Previous studies have indicated that vitamin D deficiency is linked to a risk of preeclampsia (PE). The aim of our study was to investigate the association between genetic variations in the vitamin-D receptor (VDR) gene and the susceptibility to PE in the Chinese Han population. We examined the genotypes VDR rs2228570, rs11568820 and rs1544410 in 402 PE patients and 554 normal pregnant women in the third trimester by TaqMan allelic discrimination real-time polymerase chain reaction. The clinical data of the individuals were collected to enable genotype-phenotype analysis. A significant statistical difference in the genotypic frequencies of rs2228570 between cases and controls was found (χ(2)=13.750, P=0.001). The G allele was the risk factor for the risk of PE (χ(2)=9.456, P=0.002, OR=1.137, 95% CI 1.111-1.610). There was no difference in the genotypic and allelic distributions of rs11568820 and rs1544410 between the two groups (P> 0.05). Our results provide evidence for a possible link between VDR and the development of PE in the Chinese Han population.

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Nov 20, 1998·American Journal of Obstetrics and Gynecology·G A Dekker, B M Sibai
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H YamamotoE Takeda
May 30, 2001·Molecular and Cellular Endocrinology·G K WhitfieldM R Haussler
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Augusta M A LachmeijerReynir Arngrímsson
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Aug 12, 2008·The American Journal of Clinical Nutrition·Anthony W Norman
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James D McKayMichael J Thun
Feb 19, 2009·Cancer Research·Shelley S TworogerSusan E Hankinson
Jul 7, 2009·Human Genetics·Matthew P JohnsonEric K Moses
May 7, 2010·The Journal of Dermatological Treatment·Gokhan OkanMurat Saruc
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Aug 10, 2010·American Journal of Obstetrics and Gynecology·Christopher J RobinsonDonna D Johnson
Sep 25, 2010·Placenta·J S ShinD M Nelson
Aug 24, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiao-ping XiaYun-xia Cao
Oct 12, 2012·Molecular Biology Reports·Vania B RezendeJose E Tanus-Santos
Apr 27, 2013·American Journal of Obstetrics and Gynecology·Shu-Qin WeiUNKNOWN MIROS Study Group
Jun 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Marjan TabeshAhmad Esmaillzadeh
Aug 16, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eva ÖstlundThomas Kahan
Sep 10, 2013·Journal of Korean Medical Science·Seo Kyung ChoiKye Shik Shim

❮ Previous
Next ❯

Citations

Jul 29, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Qiong MaLan Yang
Sep 30, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mitsumasa Umesawa, Gen Kobashi
Apr 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Jie XuYuping Wang
Nov 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dongxin ZhangDuyun Ye
Nov 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kaori ShinyaTatsuo Yamamoto
Sep 29, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yeshnee NaidooThajasvarie Naicker
Jan 31, 2018·Physiological Reports·Katharyn M BacaLisa M Bodnar
May 1, 2019·The Journal of Obstetrics and Gynaecology Research·Yuan Li, Yan Ruan
Apr 23, 2019·Clinical and Experimental Hypertension : CHE·Farzaneh Farajian-MashhadiSaeedeh Salimi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.