Genetic variations of HSPA1A, the heat shock protein levels, and risk of atherosclerosis.

Cell Stress & Chaperones
Elena DulínMaría C Guisasola

Abstract

HSPA1A is a serum and intracellular heat shock protein with antiapoptotic and antithrombotic properties. The present study examines the hypothesis that a decrease in the synthesis of this protein in relation to certain polymorphisms of the regulatory region of the HSPA1A gene can define a vascular disease risk phenotype. A randomly selected population was studied and stratified into groups according to the degree of vascular risk. After applying the Task Force Chart to 452 people, the subjects were divided into three groups: group 0 (no vascular risk factor or risk < 5%), n = 239; group 1 (moderate (10-20%) risk, with no clinical cardiovascular disease), n = 161; and group 2 (overt atherosclerosis), n = 52. Serum and intragranulocytic HSPA1A was quantified, and direct Sanger sequencing was performed in all subjects. An analysis was made of the association of two single nucleotide polymorphisms (db rs1008438 -110A/C and db rs1043618 +190 G/C) with circulating and intragranulocytic HSPA1A and the risk of atherosclerosis. The atherosclerotic subjects showed significantly lower circulating HSPA1A levels than the other groups, regardless of the genotype. The patients with CC genotype for both polymorphisms showed significantly lower...Continue Reading

References

Jul 13, 2001·JAMA : the Journal of the American Medical Association·R B D'AgostinoUNKNOWN CHD Risk Prediction Group
May 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jianhui ZhuStephen E Epstein
Dec 10, 2003·Hypertension·Mark WillmotPhilip M W Bath
Mar 8, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T A MehtaP T McCollum
May 17, 2005·Journal of the American College of Cardiology·Benjamin D HorneUNKNOWN Intermountain Heart Collaborative Study Group
Sep 24, 2005·Annals of the New York Academy of Sciences·Midori A YenariRona G Giffard
Feb 18, 2006·Autoimmunity Reviews·Luis J JaraMary-Carmen Amigo
Sep 9, 2006·Diabetes Research and Clinical Practice·W Lee HandYvonne Vasquez
Mar 17, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Richard S SmithGregory A Hawkins
Jun 22, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jianping LiuShaofa Nie
Nov 6, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ian GrahamUNKNOWN European Atherosclerosis Society (EAS)
Sep 11, 2007·Journal of Leukocyte Biology·Anne LeclercqJean-Baptiste Michel
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Apr 24, 2008·Molecular Medicine·James P Stice, Anne A Knowlton
Jun 26, 2008·Novartis Foundation Symposium·A Graham Pockley, Gabriele Multhoff
Jun 26, 2008·Novartis Foundation Symposium·Alexzander Asea
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Ferah ArmutcuAhmet Gurel
Jul 30, 2008·Cell Stress & Chaperones·Harm H KampingaLawrence E Hightower
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Agata Bielecka-DabrowaMaciej Banach
Apr 10, 2009·Cell Stress & Chaperones·A Graham PockleyGabriele Multhoff
Mar 20, 2010·Cell Stress & Chaperones·Xiaomin ZhangTangchun Wu
May 18, 2010·Cellular Immunology·Rajesh RamasamyRahim Md Noah
Nov 3, 2010·European Journal of Clinical Investigation·Zoltán SzeberinGyörgy Acsády
Nov 4, 2010·Cell Stress & Chaperones·Miklós KrepuskaGyörgy Acsády
Nov 3, 2011·Nature Reviews. Cardiology·Michael DomanskiScott Grundy

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Citations

Jul 31, 2013·Cell Stress & Chaperones·Malgorzata KowalczykJan Kowalski
Jul 23, 2013·International Journal of Immunogenetics·Elisa MaggioliMariaclara Cuccia
Apr 21, 2016·The Journal of Investigative Dermatology·Daiki MurasePrashiela Manga
Jan 18, 2014·Journal of Applied Physiology·Nathan T JenkinsM Harold Laughlin

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