Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study

PloS One
Marie V CoignetSong Yao

Abstract

Reproductive aging phenotypes, including age at menarche (AM) and age at natural menopause (ANM), are well-established risk factors for breast cancer. In recent years, many genetic variants have been identified in association with AM and ANM in genome-wide association studies among European populations. Using data from the Women's Circle of Health Study (WCHS) of 1,307 European-American (EA) and 1,365 African-American (AA) breast cancer cases and controls, we aimed to replicate 53 earlier GWAS variants for AM and ANM in AA and EA groups and to perform analyses on total and net reproductive lifespan (TRLS; NRLS). Breast cancer risk was also examined in relation to a polygenic risk score (PRS) for each of the reproductive aging phenotypes. We replicated a number of variants in EA women, including rs7759938 in LIN28B for AM and rs16991615 in MCM8 for ANM; whereas in the AA group, only one SNP (rs2947411 in TMEM18) for AM was directionally consistent and nominally significant. In analysis of TRLS and NRLS, several SNPs were significant, including rs466639 in RXRG that was associated with both phenotypes in both AA and EA groups. None of the PRS was associated with breast cancer risk. Given the paucity of data available among AA pop...Continue Reading

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Citations

Dec 21, 2018·Nursing Research·Theresa M HardyJacquelyn Y Taylor
Apr 2, 2019·Oxidative Medicine and Cellular Longevity·Ho-Sun LeeTaesung Park
Jun 24, 2020·Virology Journal·Qunying HanZhengwen Liu
Oct 23, 2018·NPJ Genomic Medicine·Rahul GajbhiyeGrant W Montgomery
Mar 2, 2021·Seminars in Reproductive Medicine·Joop S E Laven

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Methods Mentioned

BETA
genotyping
chip
hysterectomy

Software Mentioned

SAS
STRUCTURE

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