Genetic vulnerability, timing of short-term stress and mood regulation: A rodent diffusion tensor imaging study

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Gil ZalsmanA Weller

Abstract

Early stressful life events predict depression and anxiety in carriers of specific polymorphisms and alter brain responses but brain structural phenotypes are largely unknown. We studied the interaction between short-term stress during specific time-windows and emotion-regulation using a genetic animal model of depression, the Wistar-Kyoto (WKY) rat. Brain structural alterations were analyzed using Diffusion Tensor Imaging (DTI). WKY (n=49) and Wistar (n=55) rats were divided into experimental groups: Early stress (ES): From postnatal day (PND) 27 rats were exposed to three consecutive days of stressors; Late stress (LS): From PND 44 rats were exposed to the same protocol; No stressors. From PND 50, all animals were behaviorally tested for levels of anxiety and despair-like behaviors and then scanned. Gene×Environment×Timing (G×E×T) interactions (p=0.00022 after Hochberg correction) were found in ventral orbital cortex, cingulate cortex, external capsule, amygdala and dentate gyrus and in the emotion regulation measures. WKY showed longer immobility in forced swim test, but no effect of ES was detected. ES increased open-field anxiety-like behaviors in Wistar rats but not in WKY, possibly indicating a ceiling effect in WKY. Str...Continue Reading

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Citations

Jun 13, 2016·The Lancet. Psychiatry·Gil ZalsmanJoseph Zohar
Jul 9, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gil ZalsmanDanuta Wasserman
Sep 6, 2017·Genes, Brain, and Behavior·M A Schiele, K Domschke
Jul 3, 2018·The European Journal of Neuroscience·Sophie E WalkerCarmen Sandi
Jun 10, 2017·Frontiers in Cellular Neuroscience·Allison L McIntoshAndrew Harkin
Jul 25, 2019·Neuroscience and Biobehavioral Reviews·Lily R AleksandrovaAnthony G Phillips
Jan 27, 2021·Pediatrics·W Thomas BoyceJack P Shonkoff

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