Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence

Drug and Alcohol Dependence
Marieke HiemstraMarco P Boks

Abstract

Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13-16 with 16-20 years). Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16-20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. In conclusion, our findings support a relation between genetic risk to schizophrenia an...Continue Reading

Citations

Jun 27, 2019·BMC Gastroenterology·Lanfranco PellesiSimona Guerzoni
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Teresa Sánchez-GutiérrezAna Calvo
Aug 28, 2020·Frontiers in Human Neuroscience·Shahnaza HamidullahJibran Y Khokhar
Feb 10, 2021·Schizophrenia Bulletin·Laurie J HanniganAlexandra Havdahl
Nov 6, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hayley H A ThorpeJibran Y Khokhar
Oct 21, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Faith BorganOliver Howes

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