Genetically determined polymorphism of a form of hexokinase, HK III, found in human leucocytes.

Annals of Human Genetics
S PoveyH Harris

Abstract

1. A form of hexokinase which appears to correspond to HK III, seen in liver, spleen and lung, has been identified in human polymorphonuclear leucocytes. HK III activity has not been demonstrated in lymphocytes, permanent lymphoblastoid cell lines or in cultured fibroblasts. 2. In fresh leucocyte preparations HK III usually appeared as a single band, but in extracts of post-mortem tissues multibanded patterns were seen. Leucocyte preparations also give multi-banded patterns after storage for more than a few hours. 3. In certain individuals the HK III showed a two-banded pattern even in fresh preparations. Repeat samples and family studies suggested that this pattern was genetically determined and represented a heterozygote for a common allele HK1III and a less common variant HK2III. Out of a total of 330 English people successfully tested 10 probable heterozygotes were found. 4. It is suggested that HK III may be a monomeric enzyme whose genetic determination is independent of that of the other main forms of hexokinase.

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Citations

Aug 10, 1979·Biochimica Et Biophysica Acta·K H Ibsen, W H Fishman
Jan 5, 2001·The British Journal of Sociology·E A Stewart
Jan 22, 1996·American Journal of Medical Genetics·G A Machin, F Bamforth
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Jun 1, 1984·Research in Nursing & Health·T Tripp-Reimer
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·V GudnasonV Egilsson
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Sep 1, 1978·Metabolism: Clinical and Experimental·V R Lavis
May 1, 1988·Archives of Biochemistry and Biophysics·H M Katzen, D D Soderman

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