Genetically determined schizophrenia is not associated with impaired glucose homeostasis

Schizophrenia Research
Renato PolimantiDan J Stein

Abstract

Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Mendelian randomization analysis was well-powered, no causal relationship was observed between schizophrenia and T2D, or traits related to glucose impaired homeostasis. Similarly, we did not observe any global genetic overlap among these traits. These findings indicate that there is no causal relationships or shared mechanisms between schizophrenia and impaired glucose homeostasis.

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Citations

Sep 8, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Chun-Jen HuangChing-Hua Lin
Nov 28, 2017·Genome Medicine·Renato PolimantiUNKNOWN Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup
May 6, 2019·JAMA Network Open·Renato PolimantiUNKNOWN Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group

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