Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors.

Journal of Virology
William A McEwanB J Willett

Abstract

The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.

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Citations

Dec 14, 2011·Viruses·Julia C Kenyon, Andrew M L Lever
Mar 19, 2014·Veterinary Immunology and Immunopathology·Dorothee Bienzle
Nov 2, 2011·The Veterinary Clinics of North America. Small Animal Practice·Joanna WhiteJacqueline M Norris
Nov 10, 2009·Veterinary Immunology and Immunopathology·Sue VandeWoudeMary Poss
Jan 31, 2015·Journal of the American Chemical Society·Cristina García-SimónJoost N H Reek
Jul 26, 2005·Journal of Comparative Pathology·W S SpragueE A Hoover
May 17, 2012·Viruses·Bruno M TeixeiraMargaret J Hosie

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