Genetically Encoded Libraries of Constrained Peptides

Chembiochem : a European Journal of Chemical Biology
Tjibbe BosmaGert N Moll

Abstract

Many therapeutic peptides can still be improved with respect to target specificity, target affinity, resistance to peptidases/proteases, physical stability, and capacity to pass through membranes required for oral delivery. Several modifications can improve the peptides' properties, in particular those that impose (a) conformational constraint(s). Screening of constrained peptides and the identification of hits is greatly facilitated by the generation of genetically encoded libraries. Recent breakthrough bacterial, phage, and yeast display screening systems of ribosomally synthesized post-translationally constrained peptides, particularly those of lanthipeptides, are earning special attention. Here we provide an overview of display systems for constrained, genetically encoded peptides and indicate prospects of constrained peptide-displaying phage and bacterial systems as such in vivo.

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Citations

Oct 31, 2020·Biochemical Society Transactions·Gert N MollPawel Namsolleck
Aug 17, 2021·Frontiers in Bioengineering and Biotechnology·Caiyun LiAiying Li
Jun 28, 2019·ACS Chemical Biology·Julian D HegemannWilfred A van der Donk
Oct 5, 2021·Chembiochem : a European Journal of Chemical Biology·Daisuke FujiwaraIkuo Fujii

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