Genetically encoded voltage indicators for large scale cortical imaging come of age

Current Opinion in Chemical Biology
Thomas KnöpfelChenchen Song

Abstract

Electrical signals are fundamental to cellular sensing, communication and motility. In the nervous system, information is represented as receptor, synaptic and action potentials. Understanding how brain functions emerge from these electrical signals is one of the ultimate challenges in neuroscience and requires a methodology to monitor membrane voltage transients from large numbers of cells at high spatio-temporal resolution. Optical voltage imaging holds longstanding promises to achieve this, and has gained a fresh powerful momentum with the development of genetically encoded voltage indicators (GEVIs). With a focus on neuroimaging studies on intact mouse brains, we highlight recent advances in this field.

References

Dec 1, 1974·Biophysical Journal·W N RossH V Davila
Jul 17, 2001·The European Journal of Neuroscience·R SakaiThomas Knöpfel
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carl C H PetersenBert Sakmann
Oct 22, 2004·Nature Reviews. Neuroscience·Amiram Grinvald, Rina Hildesheim
Jan 31, 2006·Trends in Neurosciences·Thomas KnöpfelWalther Akemann
Jul 16, 2008·Nature Methods·Hidekazu TsutsuiAtsushi Miyawaki
May 20, 2009·Biophysical Journal·Walther AkemannThomas Knöpfel
Mar 7, 2005·Optics Express·Dan OronYaron Silberberg
Oct 29, 2009·Frontiers in Neuroengineering·Sunita Ghimire GautamThomas Knöpfel
Jan 13, 2010·Chemistry & Biology·Amélie PerronThomas Knöpfel
Jul 21, 2012·Journal of Neurophysiology·Walther AkemannThomas Knöpfel
Aug 31, 2012·Nature Reviews. Neuroscience·Thomas Knöpfel
Sep 6, 2012·Biophysical Journal·Yukiko MishinaThomas Knöpfel
Sep 11, 2012·Nature Methods·Amy J LamMichael Z Lin
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dougal MaclaurinAdam E Cohen
Apr 17, 2013·NeuroImage·Jeremy F P UllmannDavid C Reutens
Jul 10, 2013·The Journal of Physiology·Hidekazu TsutsuiYasushi Okamura
Jul 23, 2013·Scientific Reports·Walther AkemannThomas Knöpfel
Apr 24, 2014·Nature Communications·Yiyang GongMark J Schnitzer
Jun 24, 2014·Nature Methods·Daniel R HochbaumAdam E Cohen
Aug 15, 2014·Nature Communications·Peng ZouAdam E Cohen
Oct 18, 2014·Frontiers in Molecular Neuroscience·Yukiko MishinaThomas Knöpfel
Dec 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory ScottThomas Knöpfel
Jan 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matteo CarandiniThomas Knöpfel

Citations

Sep 16, 2015·International Journal of Molecular Sciences·Lars KaestnerPeter Lipp
Nov 28, 2015·Nature Reviews. Drug Discovery·Chenchen Song, Thomas Knöpfel
Aug 23, 2016·Frontiers in Synaptic Neuroscience·Ryuichi NakajimaBradley J Baker
Dec 15, 2015·PLoS Biology·Richard H Kramer, Christopher M Davenport
May 1, 2016·Trends in Neurosciences·Douglas A StoraceBradley J Baker
Jul 8, 2017·International Journal of Molecular Sciences·Chenchen SongThomas Knöpfel
Oct 14, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Franziska AlbersCornelius Faber
Dec 19, 2017·Chemosensors·Zhijie ChenHui-Wang Ai
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian D Gulbransen
Nov 14, 2017·Journal of Neural Engineering·Renaud SchuckSimon R Schultz
Apr 15, 2016·Journal of Neurophysiology·Srdjan D AnticThomas Knöpfel
Jan 29, 2016·Nature·Viviana Gradinaru, Nicholas C Flytzanis
Aug 30, 2016·Nature Neuroscience·Michael Z Lin, Mark J Schnitzer
Dec 13, 2018·Neural Regeneration Research·Hans E Anderson, Richard F Ff Weir
Feb 13, 2019·Frontiers in Neural Circuits·Marcus A Triplett, Geoffrey J Goodhill
Jun 20, 2019·Frontiers in Neuroinformatics·Keita WatanabeTomoki Fukai
Mar 19, 2019·Frontiers in Cellular Neuroscience·Lauren C Panzera, Michael B Hoppa
Feb 23, 2018·Frontiers in Pharmacology·Tobias BuchbornThomas Knöpfel
Dec 29, 2019·International Journal of Molecular Sciences·Alfons PenzkoferPeter Hegemann
Oct 16, 2020·Neuron·Claire RabutMikhail G Shapiro

Related Concepts

Nerve Impulses
Metazoa
Brain
Potentials, Event-Related
Fluorochromes
Luminescent Proteins
Protein Conformation
Protein Engineering
Biosensing Techniques
Fluorescence Resonance Energy Transfer

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.