Genetically engineered livestock for agriculture: a generation after the first transgenic animal research conference

Transgenic Research
J D Murray, Elizabeth A Maga

Abstract

At the time of the first Transgenic Animal Research Conference, the lack of knowledge about promoter, enhancer and coding regions of genes of interest greatly hampered our efforts to create transgenes that would express appropriately in livestock. Additionally, we were limited to gene insertion by pronuclear microinjection. As predicted then, widespread genome sequencing efforts and technological advancements have profoundly altered what we can do. There have been many developments in technology to create transgenic animals since we first met at Granlibakken in 1997, including the advent of somatic cell nuclear transfer-based cloning and gene editing. We can now create new transgenes that will express when and where we want and can target precisely in the genome where we want to make a change or insert a transgene. With the large number of sequenced genomes, we have unprecedented access to sequence information including, control regions, coding regions, and known allelic variants. These technological developments have ushered in new and renewed enthusiasm for the production of transgenic animals among scientists and animal agriculturalists around the world, both for the production of more relevant biomedical research models as ...Continue Reading

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Citations

Mar 7, 2020·Food & Function·David Julian McClements
Sep 17, 2019·World Journal of Stem Cells·Laís Vicari de Figueiredo PessôaKristine Karla Freude
Dec 22, 2017·Veterinary World·Shakil Ahmad BhatNadeem Shabir
Nov 12, 2016·Current Opinion in Biotechnology·Alison Louise Van Eenennaam
Dec 23, 2020·Annual Review of Food Science and Technology·David Julian McClementsLiangli Yu

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