Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe

Biomaterials Research
Hyojin MoonSebyung Kang

Abstract

Protein cage nanoparticles are promising nanoplatform candidates for efficient delivery systems of diagnostics and/or therapeutics because of their uniform size and structure as well as high biocompatibility and biodegradability. Encapsulin protein cage nanoparticle is used to develop a cell-specific targeting optical nanoprobe. FcBPs are genetically inserted and successfully displayed on the surface of encapsulin to form FcBP-encapsulin. Selectively binding of FcBP-encapsulin to SCC-7 is visualized with fluorescent microscopy. Encapsulin protein cage nanoparticle is robust enough to maintain their structure at high temperature and easily acquires multifunctions on demand through the combination of genetic and chemical modifications.

References

Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Jan 31, 2006·Angewandte Chemie·Rainer Haag, Felix Kratz
Dec 21, 2006·Journal of the American Chemical Society·Masaki UchidaTrevor Douglas
Jun 2, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jana TaturPedro M Matias
Oct 27, 2007·Chemistry & Biology·Giuseppe DestitoMarianne Manchester
Nov 21, 2007·Analytical Biochemistry·Yongwon JungBong Hyun Chung
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Jun 19, 2008·Advanced Drug Delivery Reviews·Conroy SunMiqin Zhang
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Jan 28, 2009·Nature Structural & Molecular Biology·Markus SutterNenad Ban
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Jul 3, 2009·Small·Aihui MahamYuehe Lin
May 11, 2010·Chembiochem : a European Journal of Chemical Biology·Deboshri BanerjeeM G Finn
Sep 25, 2010·ACS Nano·Nicholas StephanopoulosMatthew B Francis
Sep 6, 2011·Annual Review of Medicine·Andrew Z WangOmid C Farokhzad
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jian GongYitao Wang
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·William B LiechtyNicholas A Peppas
May 25, 2012·Bioconjugate Chemistry·Riki ToitaMakoto Hashizume
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Mar 27, 2013·Biomaterials·Qingbing ZengShanhe Wan
Sep 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hyojin MoonSebyung Kang

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Citations

May 20, 2018·Nature Communications·Felix SigmundGil G Westmeyer
Jul 26, 2018·Genes·Dennis DiazAnwar Sunna
Jul 2, 2020·Biomolecules·Anna N GabashviliMaxim A Abakumov
Feb 27, 2021·Frontiers in Bioengineering and Biotechnology·Hannah C YocumNancy A Da Silva
Aug 1, 2016·Current Opinion in Chemical Engineering·Maryam Raeeszadeh-SarmazdehWilfred Chen
Jul 3, 2021·Nanomaterials·Javier M RodríguezJosé R Castón
Oct 31, 2018·ACS Synthetic Biology·Elsie M WilliamsStefan Lutz
Jul 27, 2018·Molecular Pharmaceutics·Robin KlemJeroen J L M Cornelissen
Aug 22, 2021·Angewandte Chemie·Philipp LohnerClaudia Jessen-Trefzer
Nov 9, 2021·Biomacromolecules·Sandra Michel-SouzyJeroen J L M Cornelissen

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Methods Mentioned

BETA
size exclusion chromatography
chips
chip
size
transmission electron microscopy
quartz crystal microbalance
surface plasmon resonance
fluorescence imaging

Software Mentioned

MassLynx
MaxEnt1

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