Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy

Frontiers in Neurology
Brittany L AguilarPatrick A Forcelli

Abstract

Epilepsy is associated with a variety of neuropsychiatric comorbidities, including both anxiety and depression. Despite high occurrences of depression and anxiety seen in human epilepsy populations, little is known about the etiology of these comorbidities. Experimental models of epilepsy provide a platform to disentangle the contribution of acute seizures, genetic predisposition, and underlying circuit pathologies to anxious and depressive phenotypes. Most studies to date have focused on comorbidities in acquired epilepsies; genetic models, however, allow for the assessment of affective phenotypes that occur prior to onset of recurrent seizures. Here, we tested male and female genetically epilepsy-prone rats (GEPR-3s) and Sprague-Dawley controls in a battery of tests sensitive to anxiety-like and depressive-like phenotypes. GEPR-3s showed increased anxiety-like behavior in the open field test, elevated plus maze, light-dark transition test, and looming threat test. Moreover, GEPR-3s showed impaired prepulse inhibition of the acoustic startle reflex, decreased sucrose preference index, and impaired novel object recognition memory. We also characterized defense behaviors in response to stimulation thresholds of deep and intermed...Continue Reading

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Citations

Jan 8, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Dec 21, 2019·Epilepsy & Behavior : E&B·Márcio Flávio Dutra MoraesVinicius Rosa Cota
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Mar 25, 2021·Scientific Reports·Daniel GromerPaul Pauli
Sep 19, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Santiago J BallazStanley J Watson

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

ANYmaze
SPSS
GraphPad Prism
BrainMaps

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