Genetically heterogeneous mice exhibit a female survival advantage that is age- and site-specific: Results from a large multi-site study

Aging Cell
Catherine J ChengJames F Nelson

Abstract

The female survival advantage is a robust characteristic of human longevity. However, underlying mechanisms are not understood, and rodent models exhibiting a female advantage are lacking. Here, we report that the genetically heterogeneous (UM-HET3) mice used by the National Institute on Aging Interventions Testing Program (ITP) are such a model. Analysis of age-specific survival of 3,690 control ITP mice revealed a female survival advantage paralleling that of humans. As in humans, the female advantage in mice was greatest in early adulthood, peaking around 350 days of age and diminishing progressively thereafter. This persistent finding was observed at three geographically distinct sites and in six separate cohorts over a 10-year period. Because males weigh more than females and bodyweight is often inversely related to lifespan, we examined sex differences in the relationship between bodyweight and survival. Although present in both sexes, the inverse relationship between bodyweight and longevity was much stronger in males, indicating that male mortality is more influenced by bodyweight than is female mortality. In addition, male survival varied more across site and cohort than female survival, suggesting greater resistance o...Continue Reading

References

Jan 1, 1979·Beiträge zur Rheumatologie·W KeitelN Römhild
Feb 1, 1982·American Journal of Epidemiology·D L Wingard
Jan 1, 1998·The New England Journal of Medicine·J StevensJ L Wood
Oct 24, 1998·Experimental Gerontology·B A Carnes, S J Olshansky
Aug 22, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S D PletcherJ W Curtsinger
Apr 3, 2002·Evolution; International Journal of Organic Evolution·Fabian M Norry, Volker Loeschcke
Feb 15, 2003·Life Sciences·Thomas T SamarasLowell H Storms
Jul 24, 2003·Mechanisms of Ageing and Development·James M HarperRichard A Miller
May 8, 2004·Mechanisms of Ageing and Development·James M HarperRichard A Miller
Oct 20, 2004·Mechanisms of Ageing and Development·Chenxi WangDavid B Allison
Nov 6, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruth LipmanRichard A Miller
Aug 22, 2006·Research in Veterinary Science·Kimberly A GreerKeith E Murphy
Jun 21, 2007·Aging Cell·Richard A MillerRandy Strong
Oct 7, 2008·Experimental Gerontology·Alexander M KulminskiAnatoli I Yashin
Oct 8, 2008·American Journal of Clinical Oncology·Ismail JatoiPhilip S Rosenberg
Oct 1, 1947·Physiological Zoology·E A BEEMAN
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
Feb 19, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalia S Gavrilova, Leonid A Gavrilov
Oct 7, 2014·Rejuvenation Research·Jeremy M JacobsJochanan Stessman
Jun 16, 2016·Cell Metabolism·Steven N Austad, Kathleen E Fischer
Apr 12, 2017·Demography·Michal EngelmanRavi Varadhan
Mar 30, 2019·Bioinformatics·Clarice S GroeneveldMauro A A Castro

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Citations

Oct 9, 2019·The Journal of Physiology·Guadalupe L Rodríguez-GonzálezElena Zambrano
Jan 10, 2020·Nature Protocols·I BellantuonoD W Lamming
Mar 11, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elena ZambranoPeter W Nathanielsz
Jul 10, 2021·GeroScience·Adam B SalmonRandy Strong
Aug 14, 2021·The Journal of Physiology·Consuelo Lomas-SoriaElena Zambrano
Sep 12, 2021·Cell Metabolism·Dushani L PalliyaguruRafael de Cabo
Sep 24, 2021·Nature Metabolism·Suheeta RoyRobert W Williams

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Methods Mentioned

BETA
environmental stress

Software Mentioned

R Core
bshazard
R environment computing
survival

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