Genetically modified cell sheets in regenerative medicine and tissue engineering.

Biomaterials
Zhiwei JiangGuoli Yang

Abstract

Genetically modified cell sheet technology is emerging as a promising biomedical tool to deliver therapeutic genes for regenerative medicine and tissue engineering. Virus-based gene transfection and non-viral gene transfection have been used to fabricate genetically modified cell sheets. Preclinical and clinical studies have shown various beneficial effects of genetically modified cell sheets in the regeneration of bone, periodontal tissue, cartilage and nerves, as well as the amelioration of dental implant osseointegration, myocardial infarction, skeletal muscle ischemia and kidney injury. Furthermore, this technology provides a potential treatment option for various hereditary diseases. However, the method has several limitations, such as safety concerns and difficulties in controlling transgene expression. Therefore, recent studies explored efficient and safe gene transfection methods, prolonged and controllable transgene expression and their potential application in personalized and precision medicine. This review summarizes various types of genetically modified cell sheets, preparation procedures, therapeutic applications and possible improvements.

References

Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·M B MathorM De Luca
May 26, 1999·Gene Therapy·C S SeitzP A Khavari
Sep 17, 2004·The New England Journal of Medicine·Kohji NishidaYasuo Tano
Dec 2, 2006·Veterinary Research Communications·S E SuterP S Henthorn
Apr 14, 2007·The Journal of Gene Medicine·Heng-Chun ShenYu-Chen Hu
Sep 11, 2007·Journal of the American College of Cardiology·Timothy D HenryRobert L Engler
May 26, 2010·Human Gene Therapy·Zurab SiprashviliPaul A Khavari
Sep 30, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wei-Li DiWaseem Qasim
Dec 7, 2013·Biomacromolecules·Joan LeeSeung-Woo Cho
Dec 18, 2013·Human Gene Therapy. Clinical Development·Wei-Li DiWaseem Qasim
Jan 5, 2014·PloS One·Samuel McLenachanFred K Chen
Jan 7, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sandra P MeloAnthony E Oro
Jan 29, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jessica SallachHildegard Büning
Nov 28, 2014·Science Translational Medicine·Vittorio SebastianoAnthony E Oro
Feb 5, 2015·Biotechnology Journal·Eric KowarzRolf Marschalek
Sep 5, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Morgan E GramsCsaba P Kovesdy
Oct 16, 2015·Nature·Luigi Naldini
Nov 11, 2015·Human Mutation·Susana IgrejaMargarida D Amaral
Dec 9, 2015·Annual Review of Biomedical Engineering·Melissa A KottermanDavid V Schaffer
Jan 15, 2016·The Journal of Investigative Dermatology·Christos GeorgiadisWaseem Qasim
Aug 19, 2016·Critical Reviews in Biotechnology·Sanjeev K Gupta, Pratyoosh Shukla
Nov 2, 2016·JAMA : the Journal of the American Medical Association·Zurab SiprashviliM Peter Marinkovich
Nov 15, 2016·The Journal of Investigative Dermatology·Johann W BauerMichele De Luca
Dec 4, 2016·Advanced Drug Delivery Reviews·Jayoung KimJordan J Green
Dec 10, 2016·Molecular Therapy. Methods & Clinical Development·Jonathan DashkoffEloise Hudry
Dec 17, 2016·Nature Reviews. Drug Discovery·Yanhong ShiShinya Yamanaka
Feb 28, 2017·Nature Reviews. Nephrology·Lakhmir S ChawlaUNKNOWN Acute Disease Quality Initiative Workgroup 16.

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