Genetically modified HLA class I molecules able to inhibit human NK cells without provoking alloreactive CD8+ CTLs

The Journal of Immunology : Official Journal of the American Association of Immunologists
Alexandra SharlandGerald L Waneck

Abstract

Human NK cells are likely to be important effectors of xenograft rejection. Expression of HLA class I molecules by transfected porcine cells can protect them from human NK cell-mediated lysis; however, this strategy has the potential to augment the anti-graft response by recipient CD8(+) T cells recognizing foreign pig peptides presented by HLA. In this study we show that the introduction of a mutation (D227K) in the alpha(3) domain of HLA-Cw3 abrogates its recognition by CD8-dependent T cells but leaves intact its ability to function as an inhibitory ligand for NK cells. Such genetically modified molecules may have potential therapeutic applications in the prevention of delayed xenograft rejection and in the facilitation of allogeneic and xenogeneic bone marrow engraftment.

References

Jun 1, 1976·The Journal of Experimental Medicine·M A Skinner, J Marbrook
Jan 1, 1990·International Immunology·D LuryN Holmes
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Jan 1, 1989·Advances in Immunology·G Trinchieri
Apr 2, 1987·Nature·Z DembićH von Boehmer
Jun 19, 1985·Journal of Chromatography·H W Lahm, S Stein
Jan 1, 1983·Immunological Reviews·S L Swain
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Oct 1, 1994·Veterinary Immunology and Immunopathology·D H Sachs
Jan 1, 1993·Transplant Immunology·M de Bueger, E Goulmy
Jan 1, 1993·Annual Review of Immunology·L A Sherman, S Chattopadhyay
Aug 1, 1996·Immunology Today·J A Frearson, D R Alexander
Oct 1, 1996·Current Opinion in Immunology·J L Platt
Mar 1, 1997·Immunity·O MandelboimJ L Strominger
Mar 5, 1998·Nature·V M BraudA J McMichael
May 23, 1998·Annual Review of Immunology·H Auchincloss, D H Sachs
Oct 31, 1998·Current Opinion in Immunology·J O Manilay, M Sykes
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·S D WainwrightC H Holmes

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Citations

Jun 16, 2007·Nature Reviews. Immunology·Yong-Guang Yang, Megan Sykes
Jun 19, 2012·Xenotransplantation·David K C CooperRichard N Pierson
Feb 8, 2018·Journal of Immunology Research·Gisella Puga YungJörg D Seebach
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pietro ForteJörg D Seebach
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Pietro ForteJörg D Seebach
Jan 21, 2012·Current Opinion in Organ Transplantation·Hui Wang, Yong-Guang Yang
Oct 31, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena BoksaDaniel Lipiński
Aug 6, 2005·Transplantation·Christopher BurlakMichael A Rees
Aug 22, 2003·Clinical and Experimental Immunology·M C HonoratiA Facchini
Aug 21, 2010·Xenotransplantation·Yong-Guang Yang
May 11, 2007·Xenotransplantation·Mark D Crew
Aug 8, 2008·Current Opinion in Organ Transplantation·Mårten K J Schneider, Jörg D Seebach
Oct 3, 2009·Xenotransplantation·Richard N PiersonDavid K C Cooper
Jan 8, 2021·International Journal of Immunogenetics·Marco Carvalho-OliveiraConstanca Figueiredo

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