Genetically Modified Mesenchymal Stromal/Stem Cells: Application in Critical Illness.

Stem Cell Reviews and Reports
Amir K VarkouhiClaudia C Dos Santos

Abstract

Critical illnesses including sepsis, acute respiratory distress syndromes, ischemic cardiovascular disorders and acute organ injuries are associated with high mortality, morbidity as well as significant health care system expenses. While these diverse conditions require different specific therapeutic approaches, mesenchymal stem/stromal cell (MSCs) are multipotent cells capable of self-renewal, tri-lineage differentiation with a broad range regenerative and immunomodulatory activities, making them attractive for the treatment of critical illness. The therapeutic effects of MSCs have been extensively investigated in several pre-clinical models of critical illness as well as in phase I and II clinical cell therapy trials with mixed results. Whilst these studies have demonstrated the therapeutic potential for MSC therapy in critical illness, optimization for clinical use is an ongoing challenge. MSCs can be readily genetically modified by application of different techniques and tools leading to overexpress or inhibit genes related to their immunomodulatory or regenerative functions. Here we will review recent approaches designed to enhance the therapeutic potential of MSCs with an emphasis on the technology used to generate geneti...Continue Reading

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Citations

Oct 19, 2020·Stem Cell Reviews and Reports·Akram NadiShiva Asadpour
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Asim Cengiz AkbulutLeon J Schurgers
Apr 4, 2021·International Journal of Molecular Sciences·Yoojin SeoHyung-Sik Kim
Jun 3, 2021·International Journal of Molecular Sciences·Saeyoung Park, Sung-Chul Jung
May 27, 2021·Stem Cells International·Mehrdad Afarid, Fatemeh Sanie-Jahromi
Aug 23, 2021·Stem Cell Research & Therapy·Mai AbdelgawadAhmed Lotfy

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Methods Mentioned

BETA
pharmacotherapy
gene modification
transfection
transfect
bronchoalveolar lavage
genetic modification
fluorescence imaging
genetic modifications

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