Genetically predicted iron status and life expectancy.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Iyas Daghlas, Dipender Gill

Abstract

Systemic iron status affects multiple health outcomes, however its net effect on life expectancy is not known. We conducted a two-sample Mendelian randomization (MR) study to investigate the association of genetically proxied iron status with life expectancy. Using genetic data from 48,972 individuals, we identified three genetic variants as instrumental variables for systemic iron status. We obtained genetic associations of these variants with parental lifespan (n = 1,012,240) and individual survival to the 90th vs. 60th percentile age (11,262 cases and 25,483 controls). We used the inverse-variance weighted method to estimate the effect of a 1-standard deviation (SD) increase in genetically predicted serum iron on each of the life expectancy outcomes. We found a detrimental effect of genetically proxied higher iron status on life expectancy. A 1-SD increase in genetically predicted serum iron corresponded to 0.70 (95% confidence interval [CI] -1.17, -0.24; P = 3.00 × 10-3) fewer years of parental lifespan and had odds ratio 0.81 (95% CI 0.70, 0.93; P = 4.44 × 10-3) for survival to the 90th vs. 60th percentile age. We did not find evidence to suggest that these results were biased by pleiotropic effects of the genetic variants...Continue Reading

References

Jan 14, 2011·Clinical Chemistry·Christina EllervikBørge G Nordestgaard
Oct 30, 2014·Nature Communications·Beben BenyaminJohn B Whitfield
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Dipender GillAbbas Dehghan
Aug 16, 2019·Nature Communications·Joris DeelenJoanne M Murabito
Feb 12, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shuai Yuan, Susanna Larsson

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Elena GammellaStefania Recalcati
Nov 21, 2020·Cell Metabolism·Jiashuo Zheng, Marcus Conrad
Aug 18, 2021·Stroke; a Journal of Cerebral Circulation·Marios K Georgakis, Dipender Gill

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