Genetics and epigenetics of varicocele pathophysiology: an overview

Journal of Assisted Reproduction and Genetics
Viviane Paiva SantanaRosana Maria Dos Reis

Abstract

Varicocele is found in approximately 20% of adults and adolescents and in 19-41% of men seeking treatment for infertility. It is associated with a decrease in sperm count as well as sperm motility and morphology. The currently accepted description of the pathophysiology of varicocele does not explain all its clinical manifestations; therefore, other factors such as genetic and epigenetic changes, associated with the environment, might be involved in causing infertility and decrease in sperm quality. It has been reported that the varicocele-induced deterioration of testicular function is progressive and interferes with fertility; hence, early and efficient assessment of the genetic manifestations in patients would be important for developing future medical interventions. Chromosomal disorders, mutations, polymorphisms, changes in gene expression, and epigenetic changes have all been reported to be associated with varicocele. Several studies are underway to unravel the genetic basis of this disease, as it is important to understand the origin and the aggravating factors to ensure appropriate guidance and intervention. Here, we review the available literature regarding the genetic and epigenetic changes associated with varicocele,...Continue Reading

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Citations

Jun 14, 2018·Andrologia·Nancy W MikhaelTaymour Mostafa
Jan 3, 2019·Systems Biology in Reproductive Medicine·Viviane Paiva SantanaRosana Maria Dos Reis
Mar 20, 2020·Andrologia·Zahra DarmishonnejadMohammad Hossein Nasr-Esfahani
Jun 6, 2020·Journal of Developmental Origins of Health and Disease·N MuhammadK H Erlwanger
Dec 18, 2018·Frontiers in Genetics·Xiaolei LiuLu Shen
Feb 9, 2021·Human Antibodies·Nahal EshghifarFarkhondeh Pouresmaeili
Jan 20, 2021·Fertility and Sterility·Viviane P Santana, Sandro C Esteves

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