PMID: 751648Dec 1, 1978Paper

Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozyme on chromosome 4

Biochemical Genetics
R S Holmes

Abstract

Electrophoretic variants for the mitochondrial isozyme of aldehyde dehydrogenase (AHD) have been observed in inbred strains and in Harwell linkage testing stocks of Mus musculus. F1 (LVC X C57BL/Go) mice showed a codominant allele three-bounded phenotype, which suggests a dimeric subunit structure (designated AHD-A2). The anodal-migrating supernatant isozyme of AHD was electrophoretically invariant among the 23 inbred strains and stocks examined. The genetic locus encoding AHD-A2 (suggested name Ahd-1) is localized on chromosome 4 and was mapped close to je (jerker) and Gpd-1 (encoding the liver and kidney isoenzyme of glucose-6-phosphate dehydrogenase). Ontogenetic analyses demonstrated that both AHD isozymes exhibited low activity in late fetal and early neonatal liver and kidney extracts, and reached adult levels within 3 weeks of birth.

References

Oct 1, 1976·Archives of Biochemistry and Biophysics·C SiewV G Erwin
Aug 1, 1976·Archives of Biochemistry and Biophysics·J H Eckfeldt, T Yonetani
Feb 1, 1975·Archives of Biochemistry and Biophysics·R A DeitrichG Erwin
Apr 1, 1975·Archives of Biochemistry and Biophysics·A A Horton, M C Barrett
Jul 27, 1975·Biochimica Et Biophysica Acta·T Koivula, M Koivusalo
Nov 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·D S Madge
Oct 1, 1972·European Journal of Biochemistry·H I ThiedenL Sestoft
Apr 1, 1972·Biochemical Genetics·J G WatsonS Chaykin
Jan 1, 1972·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·R Robinson

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Citations

Jan 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J P StoyeS Best
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A AndalibiA J Lusis
Dec 1, 1981·Biochemical Genetics·N Truesdale-MahoneyH Weiner
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C M AbbottR Wiseman
Jan 11, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R BlankB Mock
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H Nadeau, M Kosowsky
Jan 1, 1985·The International Journal of Biochemistry·E M Algar, R S Holmes
Sep 30, 1987·Mechanisms of Ageing and Development·U K RoutR S Holmes
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T L SeeleyR S Holmes
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·U K Rout, R S Holmes
Sep 1, 1987·Genomics·A G SearleV J Buckle
Dec 1, 1985·Alcoholism, Clinical and Experimental Research·R S Holmes
May 1, 1985·Alcoholism, Clinical and Experimental Research·J A DuleyR S Holmes
Jan 1, 1981·Animal Blood Groups and Biochemical Genetics·R S Holmes, G P Timms
Jun 26, 2020·Molecular Biotechnology·Seyoung LeeJiho Min

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