Genetics and Pathogenesis of Inflammatory Bowel Disease.

Annual Review of Pathology
Ta-Chiang Liu, Thaddeus S Stappenbeck

Abstract

We are currently in an exciting time when our understanding of genetic underpinnings of inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel genotyping and sequencing technologies. With >160 susceptible loci identified for IBD, the goal is now to understand at a fundamental level the function of these susceptibility alleles. Determining the clinical relevance of how these susceptible genes shape the development of IBD is also a high priority. The main challenge is to understand how the environment and microbiome play a role in triggering disease in genetically susceptible individuals, as the interactions may be complex. To advance the field, novel in vitro and mouse models that are designed to interrogate complex genetics and functionally test hypotheses are needed. Ultimately, the goal of genetics studies will be to translate genetics to patients with IBD and improve their care.

References

Sep 1, 1984·International Journal of Epidemiology·P G Smith, N E Day
Oct 13, 2001·The New England Journal of Medicine·J KeaneM M Braun
Jul 23, 2004·Nature·Michael MorleyVivian G Cheung
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Nov 8, 2005·Nature Genetics·Torkel VangNunzio Bottini
Sep 18, 2007·Nature Genetics·Anna L DixonWilliam O C Cookson
Apr 10, 2008·Nature Reviews. Genetics·Mark I McCarthyJoel N Hirschhorn
Feb 19, 2009·Nature Reviews. Genetics·William CooksonMark Lathrop
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Sep 18, 2010·Inflammatory Bowel Diseases·Talin HarituniansDermot P B McGovern
Feb 3, 2011·Inflammatory Bowel Diseases·Lina-Marcela Diaz-GalloJavier Martin
Feb 25, 2011·Arthritis Research & Therapy·Adrian Cortes, Matthew A Brown
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Jordan S OrangeHakon Hakonarson
May 3, 2011·Gastroenterology·Judy H Cho, Steven R Brant
Jun 17, 2011·Nature·Bernard KhorRamnik J Xavier
Oct 4, 2011·Cell·Herbert W Virgin, John A Todd
Oct 19, 2011·Nature Reviews. Genetics·Constantin Polychronakos, Quan Li
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sharon GreenblumElhanan Borenstein
Jan 21, 2012·Journal of Crohn's & Colitis·Stephanie VerschuereClaude A Cuvelier
Feb 22, 2012·Gut·Jonas F LudvigssonCarolina Ciacci
Apr 20, 2012·Nature Immunology·Inmoo Rhee, André Veillette
Jul 31, 2012·Gut·Fiona D M van SchaikH Bas Bueno-de-Mesquita
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Aug 24, 2012·Lancet·Ingrid OrdásWilliam J Sandborn
Oct 19, 2012·The New England Journal of Medicine·William J SandbornUNKNOWN CERTIFI Study Group
Dec 18, 2012·The Journal of Clinical Investigation·Giovanna LeoniAsma Nusrat

❮ Previous
Next ❯

Citations

May 11, 2016·Journal of Gastroenterology·Shinya SugimotoTakanori Kanai
Jul 3, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Jun Miyoshi, Eugene B Chang
Oct 7, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Sophie RestelliniJean-Louis Frossard
Oct 28, 2016·The Journal of Pathology·Werna Tc Uniken VenemaEleonora Am Festen
Oct 13, 2016·Gastroenterology·Thaddeus S Stappenbeck, Dermot P B McGovern
Nov 22, 2016·Scandinavian Journal of Gastroenterology·Guangxi ZhouZhanju Liu
Apr 12, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Bruno LamasHarry Sokol
Aug 31, 2016·Inflammatory Bowel Diseases·Fernando LopesDerek M McKay
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·John B Grigg, Gregory F Sonnenberg
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yujie ShenYingwei Chen
Jan 13, 2018·Frontiers in Immunology·Xuemei ZhangJian Ma
Aug 24, 2018·The Journal of Clinical Investigation·Ta-Chiang LiuThaddeus S Stappenbeck
Feb 23, 2019·Cellular & Molecular Immunology·Hongdi MaShu Zhu
Dec 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mel Pilar EspaillatLina M Obeid
Jan 13, 2018·The American Journal of Surgical Pathology·Vanderlene Liu KungChangqing Ma
May 21, 2020·Cell Research·Danping ZhengEran Elinav
Jul 7, 2019·Seminars in Immunopathology·Markus F Neurath, Moritz Leppkes
May 10, 2018·Journal of Natural Medicines·Aiguo Ding, Xianhui Wen
Jun 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Matthew T HenkeJon Clardy
Dec 11, 2019·Cells·Farzana ParveenLiang-Yin Ke
Apr 8, 2020·Frontiers in Immunology·Charles Caër, Mary Jo Wick
Sep 30, 2016·World Journal of Gastroenterology : WJG·Che-Yung ChaoTalat Bessissow
May 10, 2019·Journal of Cellular Biochemistry·Hamid Asadzadeh-AghdaeiMohammad Reza Zali
May 28, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Kwang Il Seo, Sang-Bum Kang

❮ Previous
Next ❯

Methods Mentioned

BETA
exome sequencing
targeted knockout
genotyping
chips
RNA-seq
biopsies
gene trap

Software Mentioned

Immunochip

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Annual Review of Biochemistry
Yosef Gruenbaum
Annual Review of Biomedical Engineering
Timothy P PaderaLance L Munn
Annual Review of Pathology
Jochen Herms, Mario M Dorostkar
Annual Review of Pathology
James T Neal, Calvin J Kuo
© 2022 Meta ULC. All rights reserved