Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma

Current Ophthalmology Reports
Niraj Nathan, Rachel W Kuchtey

Abstract

Recent studies have shed new light on the genetic factors underlying pseudoexfoliation syndrome, growing our understanding of the role of the lysyl oxidase-like 1 (LOXL1) gene and its various polymorphisms as well as identifying new genetic associations. Recent years have brought new insight on how these genetic factors interact with other factors, including environmental, to confer risk to individuals and populations worldwide. All of these findings may hold importance to the screening, diagnosis, and monitoring of pseudoexfoliation and may also help lead to the identification of novel therapeutic targets. This review serves as an update on the recent trends and findings in pseudoexfoliation syndrome.

References

Jun 1, 1997·Acta Ophthalmologica Scandinavica·A RingvoldL Sandvik
Dec 31, 1997·American Journal of Ophthalmology·P MitchellW Smith
Feb 1, 2000·American Journal of Ophthalmology·K R ShrumD Hodge
May 24, 2001·The British Journal of Ophthalmology·R R AllinghamE Stefánsson
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Feb 11, 2003·Journal of Cellular Biochemistry·Herbert M Kagan, Wande Li
Mar 19, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kirsti GrødumBo Bengtsson
Aug 5, 2004·Acta Ophthalmologica Scandinavica·J S RitlandS O Semb
Mar 5, 2005·Ophthalmology·Kirsti GrødumBo Bengtsson
Nov 14, 2008·Journal of Cataract and Refractive Surgery·Bradford J ShingletonSonalee Desai-Bartoli
Oct 27, 2009·Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Feb 10, 2010·Middle East African Journal of Ophthalmology·Allison Angelilli, Robert Ritch
May 12, 2010·Archives of Ophthalmology·Leslie HymanUNKNOWN Early Manifest Glaucoma Trial Group
Jan 8, 2011·Investigative Ophthalmology & Visual Science·Bao Jian FanJaney L Wiggs
Dec 27, 2011·Ophthalmology·John LandersPeter Watson
Feb 11, 2012·Journal of Cataract and Refractive Surgery·Jessica L M TingUNKNOWN Trabectome Study Group
Nov 20, 2012·Human Genomics·Eman ElhawyJohn Danias
Jul 3, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias K J KlamannEckart Bertelmann
Oct 26, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jens F JordanMatthias Neuburger
Feb 22, 2014·European Journal of Ophthalmology·Ahti H A Tarkkanen, Tero T Kivelä
Mar 29, 2014·Acta Ophthalmologica·Rebecka Svensson, Curt Ekström
May 23, 2014·International Ophthalmology·Olusola O OlawoyeRobert Ritch
May 27, 2014·American Journal of Ophthalmology·Jae H KangLouis R Pasquale
Sep 13, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Randolf A WidderThomas S Dietlein
Oct 14, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cord HuchzermeyerAnselm G M Jünemann
Feb 14, 2015·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ece Turan-VuralNejla Dikmen
Apr 29, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias K J KlamannEckart Bertelmann
Sep 24, 2015·European Journal of Ophthalmology·Tolga KocaturkYelda O Dayanir
Oct 4, 2015·Journal of Cataract and Refractive Surgery·Charlotta ZetterströmMats Lundström
Nov 1, 2015·Progress in Brain Research·Stefano Miglior, Francesca Bertuzzi

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