Genetics in chronic venous disease

Phlebology
Yasmin GrantAlun Davies

Abstract

Chronic venous disease is highly prevalent in the Western world, with varicose veins being the most common form of clinical manifestation. With recent developments in sequencing technology, clinicians and geneticists alike are embarking on a journey to identify and unravel the genetic candidates of chronic venous disease. There is now currently substantial evidence to suggest the presence of genetic influences in the aetiology and pathology of venous disease. Despite this, the precise nature and profile of the genes involved in chronic venous disease remain a poorly understood entity. Moreover, it is strikingly apparent that the majority of venous genetic studies conducted over the past decade do not adhere to fundamental research principles. The emergence of high-throughput genotyping platforms permits a more systematic search for inherited components of venous disease. Pursuing a genome-wide frontier has the potential to reveal novel critical metabolic pathways and explain the genetic susceptibility of chronic venous disease. An expedited knowledge of the genetic factors in the aetiology of venous disease may translate into better prevention or treatment, which would benefit patients suffering from its clinical sequelae. Rese...Continue Reading

References

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Citations

Nov 30, 2018·British Journal of Haematology·Matthew K H TanAlun H Davies
Apr 19, 2019·PLoS Genetics·Alexandra S ShadrinaYakov A Tsepilov
Sep 25, 2020·Tissue Engineering. Part B, Reviews·Alicia Fernández-Colino, Stefan Jockenhoevel
Aug 7, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Diane T SmelserDavid J Carey

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Methods Mentioned

BETA
genotyping

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