Genetics of absence epilepsy in rats

Behavior Genetics
B W PeetersA M Coenen

Abstract

All rats of the WAG inbred strain show electrophysiological and behavioral phenomena reminiscent of human absence epilepsy. To study the genetic architecture of this kind of epilepsy, WAG rats were cross bred with inbred ACI rats which show no signs of epilepsy. Number and duration of spike-wave discharges per hour were determined from 24-h recordings of cortical EEG in parental strains and reciprocal F1 hybrids. All hybrids showed spike-wave discharges, indicating complete dominance for occurrence, but different genetic backgrounds were suggested for number and duration of the phenomena. These results imply that more than one gene is involved in absence epilepsy. Some genes determine the occurrence, while others may manipulate the actual number and duration of the epileptic phenomena.

References

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Citations

Jul 1, 1990·Physiology & Behavior·M InoueA M Coenen
Jul 1, 1992·Epilepsy Research·A M CoenenE L van Luijtelaar
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Oct 6, 2006·Social Biology·Lee Ellis
Jan 1, 1992·Acta Neurologica Scandinavica. Supplementum·D LindhoutD G Kasteleijn-Nolst Trenité
Aug 19, 2014·Neurobiology of Disease·Gilles van LuijtelaarMartin J Gallagher
Jan 1, 1991·Journal of Receptor Research·C M van RijnA M Coenen
Dec 3, 2014·Brain Research·Evgenia SitnikovaVladimir V Raevsky
Jul 6, 2006·The European Journal of Neuroscience·Ulrich SchriddeGilles van Luijtelaar
Mar 15, 2005·Physiology & Behavior·Ulrich Schridde, Gilles van Luijtelaar
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·Ulrich Schridde, Gilles van Luijtelaar
Feb 13, 2004·Genes, Brain, and Behavior·U Schridde, G van Luijtelaar

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Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.