Genetics of aggressive behavior: An overview

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Kim VeroudeStephen V Faraone

Abstract

The Research Domain Criteria (RDoC) address three types of aggression: frustrative non-reward, defensive aggression and offensive/proactive aggression. This review sought to present the evidence for genetic underpinnings of aggression and to determine to what degree prior studies have examined phenotypes that fit into the RDoC framework. Although the constructs of defensive and offensive aggression have been widely used in the animal genetics literature, the human literature is mostly agnostic with regard to all the RDoC constructs. We know from twin studies that about half the variance in behavior may be explained by genetic risk factors. This is true for both dimensional, trait-like, measures of aggression and categorical definitions of psychopathology. The non-shared environment seems to have a moderate influence with the effects of shared environment being unclear. Human molecular genetic studies of aggression are in an early stage. The most promising candidates are in the dopaminergic and serotonergic systems along with hormonal regulators. Genome-wide association studies have not yet achieved genome-wide significance, but current samples are too small to detect variants having the small effects one would expect for a comp...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T R Insel, L E Shapiro
Mar 26, 1986·Brain Research·J P DaVanzoM S Swanson
Nov 1, 1970·Journal of the Experimental Analysis of Behavior·D R Cherek, R Pickens
Mar 1, 1981·Behavior Genetics·G A van Oortmerssen, T C Bakker
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·F SluyterG A van Oortmerssen
Apr 1, 1995·Physiology & Behavior·T R InselJ T Winslow
Oct 23, 1997·Behavior Genetics·F SluyterG A van Oortmerssen
Nov 30, 2000·Psychological Medicine·J EvansD Nutt
Jun 21, 2001·Psychiatric Genetics·E G JönssonM Schalling
Oct 30, 2001·Behavioural Brain Research·K A MiczekS Faccidomo
Feb 6, 2002·Brain Research Bulletin·Yann S Mineur, Wim E Crusio
Feb 22, 2002·American Journal of Medical Genetics·Susan E YoungJohn K Hewitt
Jul 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rosa M M de Almeida, Klaus A Miczek
Jul 20, 2002·Brain Research. Developmental Brain Research·Ellen G DuysenOksana Lockridge
Aug 6, 2002·Science·Avshalom CaspiRichie Poulton
Oct 26, 2002·Molecular Psychiatry·D RujescuH-J Möller
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Jan 16, 2003·Physiology & Behavior·Stephen B ManuckRobert E Ferrell

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Citations

Apr 20, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Karim MalkiMaria Grazia Tosto
Aug 4, 2016·Scientific Reports·Zhenhui LiXiquan Zhang
Apr 27, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dimitry A Chistiakov, Vladimir P Chekhonin
Nov 10, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Charlotte A M CecilEamon J McCrory
Dec 12, 2018·Psychological Medicine·Brooke L SlawinskiS Alexandra Burt
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Richard W Wrangham
Nov 20, 2019·Current Psychiatry Reports·Selena R MagalottiMolly K McVoy
Jan 10, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I Hyun RuischPieter J Hoekstra
Aug 30, 2019·Psychiatric Genetics·Veronika V OdintsovaDorret I Boomsma
May 7, 2020·Evolution; International Journal of Organic Evolution·Reuven DukasCarling M Baxter
Feb 19, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Karim MalkiPhilip Asherson
Nov 18, 2018·Translational Psychiatry·Elena V CherepkovaLyubomir I Aftanas
Jun 29, 2018·Frontiers in Behavioral Neuroscience·Sara PalumboSilvia Pellegrini
Apr 8, 2020·Frontiers in Behavioral Neuroscience·Scott H DeibelNathan J Kolla
Apr 19, 2018·Frontiers in Behavioral Neuroscience·Marjolein M J van DonkelaarJanita Bralten
Jun 3, 2018·Molecular Psychiatry·Yanli Zhang-JamesStephen V Faraone
Jun 30, 2019·Nature Reviews. Disease Primers·Graeme FairchildStephane A De Brito
Aug 28, 2019·Journal of Child and Adolescent Psychopharmacology·Daniel F ConnorJan K Buitelaar
Jul 14, 2020·Aggressive Behavior·Bojana M DinićZoran Budimlija
Aug 1, 2020·Animals : an Open Access Journal From MDPI·Irene CamerlinkSimon P Turner
Mar 30, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erlend J BrevikTetyana Zayats
Aug 14, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Aet O'LearyJaanus Harro
Feb 20, 2021·Translational Psychiatry·Alexios-Fotios A MentisGeorge P Chrousos
Jun 29, 2016·Neuroscience and Biobehavioral Reviews·Jessica E Salvatore, Danielle M Dick
Jul 17, 2021·Biological Psychiatry·Sofi da Cunha-Bang, Gitte Moos Knudsen
Aug 1, 2021·Translational Psychiatry·Hill F IpDorret I Boomsma
Aug 15, 2021·Behavior Genetics·Camiel M van der LaanDorret I Boomsma
Aug 24, 2021·Journal of Neural Transmission·David ChecknitaKent W Nilsson

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