Genetics of antigen processing and presentation

Immunogenetics
Adrian Kelly, J Trowsdale

Abstract

Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to control of specificity of antigen presentation. Processing of the antigen, to peptides or other moieties, requires other sets of molecules. For classical class I, this includes TAP peptide transporters, proteasome components and Tapasin, genes which are encoded within the MHC. Similarly, HLA-DO and -DM, which influence presentation by HLA class II molecules, are encoded in the MHC region. Analysis of MHC mutants, including point mutations and large deletions, has been central to understanding the roles of these genes. Mouse genetics has also played a major role. Many other genes have been identified including those controlling expression of HLA class I and class II at the transcriptional level. Another genetic approach that has provided insight has been the analysis of microorganisms, including viruses and bacteria that escape immune recognition by blocking these antigen processing and presentation pathways. Here, we provide a brief history of the genetic approaches, both traditional and modern, that have been used in the quest to understand antigen processing and presentation.

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Citations

Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Oct 20, 2019·Cells·Jerzy K KulskiJohannes M Dijkstra
May 3, 2020·International Journal of Immunogenetics·Corrine M C HeijmansRonald E Bontrop
Oct 28, 2019·Oncoimmunology·Jenny SprootenAbhishek D Garg
Apr 11, 2020·International Journal of Molecular Sciences·Achamaporn PunnanitinontSantosh K Patnaik
Apr 1, 2020·HLA : Immune Response Genetics·Jonathan A M LucasNeema P Mayor
Oct 28, 2019·Bioscience Reports·Vaishnavi U WarrierRajesh Kumar Gupta
Apr 16, 2020·Journal of Clinical Medicine·Rashi JainJun-O Jin
Oct 29, 2020·International Journal of Immunogenetics·Milena Ivanova, Velizar Shivarov
Feb 12, 2021·Frontiers in Immunology·Jamal Hussen, Hans-Joachim Schuberth
Mar 27, 2021·Frontiers in Immunology·Karthik DhatchinamoorthyKenneth L Rock
Apr 17, 2021·EMBO Reports·Isabel Castro-PiedrasKevin Pruitt
Jul 14, 2019·Critical Reviews in Oncology/hematology·Sadal RefaeGerard Milano
May 1, 2021·Life·Wanda Niepiekło-MiniewskaPiotr Kuśnierczyk
Jun 29, 2021·Animal Models and Experimental Medicine·Feng LiXiaohui Zhou

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Methods Mentioned

BETA
peptide exchange
CLIP

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