Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans

Psychiatry and Clinical Neurosciences
Mihoko Shimada-SugimotoJohn M Hettema

Abstract

This review provides a broad overview of the state of research in the genetics of anxiety disorders (AD). Genetic epidemiological studies report a moderate level of familial aggregation (odds ratio: 4-6) and heritability estimates are about 30-50%. Twin studies suggest that the genetic architecture of AD is not isomorphic with their classifications, sharing risk factors with each other. So far, linkage and association studies of AD have produced inconclusive results. Genome-wide association studies of AD can provide an unbiased survey of common genetic variations across the entire genome. Given the shared causes of AD that transcend our current diagnostic classifications, clustering anxiety phenotypes into broader groups may be a powerful approach to identifying susceptibility locus for AD. Using such a shared genetic risk factor, meta-analyses of genome-wide association studies of AD conducted by large consortia are needed. Environmental factors also make a substantial contribution to the cause of AD. Although candidate gene studies of gene by environmental (G × E) interaction have appeared recently, no genome-wide search for G × E interactions have been performed. Epigenetic modification of DNA appears to have important effec...Continue Reading

References

Mar 1, 1990·Archives of General Psychiatry·A J FyerD F Klein
Mar 1, 1986·Archives of General Psychiatry·R NoyesD R Chaudhry
Nov 7, 1980·Science·A Razin, A D Riggs
Oct 9, 1980·Nature·B K Duncan, J H Miller
Jan 1, 1999·Trends in Pharmacological Sciences·J J Soghomonian, D L Martin
Mar 20, 2001·Archives of General Psychiatry·K S KendlerM C Neale
Aug 10, 2001·American Journal of Medical Genetics·J GelernterS Goodson
Oct 2, 2001·The American Journal of Psychiatry·J M HettemaK S Kendler
Jan 2, 2004·The American Journal of Psychiatry·Joel GelernterScott W Woods
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Srijan SenDebashis Ghosh
Feb 9, 2005·Archives of General Psychiatry·John M HettemaKenneth S Kendler
May 2, 2006·The American Journal of Psychiatry·John M HettemaKenneth S Kendler
Jun 21, 2006·Journal of Psychopharmacology·Murray EslerGavin Lambert
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Murray B SteinJoel Gelernter
Feb 23, 2008·Annals of Medicine·Iiris Hovatta, Carrolee Barlow
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Elisabeth B BinderKerry J Ressler
Apr 17, 2008·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jordan W Smoller, Stephen V Faraone
Jun 10, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Tim F OberlanderAngela M Devlin
Jan 6, 2009·Annals of the New York Academy of Sciences·Murray EslerElisabeth Lambert
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
Jan 24, 2009·Journal of Human Genetics·Takeshi OtowaYuji Okazaki
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Sep 10, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Steven R H BeachRobert A Philibert
Sep 15, 2009·Depression and Anxiety·Charles F GillespieKerry J Ressler
Oct 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Kristian TambsKenneth S Kendler
Oct 28, 2009·Nature Reviews. Genetics·Robert PlominOliver S P Davis
Nov 10, 2009·Nature Neuroscience·Chris MurgatroydDietmar Spengler
Dec 5, 2009·Journal of Human Genetics·Takeshi OtowaTsukasa Sasaki
Jan 6, 2010·Molecular Psychiatry·E MaronJ Shlik
Jan 30, 2010·Depression and Anxiety·Benedikt KlaukeKatharina Domschke

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Citations

Dec 15, 2015·European Eating Disorders Review : the Journal of the Eating Disorders Association·Melissa A Munn-Chernoff, Jessica H Baker
May 6, 2016·Journal of Neural Transmission·Eli R LebowitzRuth Feldman
May 10, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erin C DunnJordan W Smoller
May 20, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jeanne E SavageJohn M Hettema
Jun 29, 2016·Lancet·Michelle G Craske, Murray B Stein
Mar 19, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Jonathan R I ColemanThalia C Eley
Dec 16, 2016·Psychological Medicine·N R ZilhãoC V Dolan
Jun 24, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku Kim, Ho-Kyoung Yoon
Dec 12, 2017·Genes, Brain, and Behavior·Danielle M DickJinni Su
May 26, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca T EmenyKarl-Heinz Ladwig
Jun 23, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yoon-Mi HurSiwoo Lee
Nov 26, 2019·Behavioral Sleep Medicine·Christina A MartinEmma Sciberras
Dec 31, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·John M HettemaMurray B Stein
Aug 30, 2019·Psychiatric Genetics·Maria SchermaPaola Fadda
May 21, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Mira VasilevaFranz Petermann
Jun 9, 2020·Annals of Internal Medicine·Kimberly D GregoryUNKNOWN Women’s Preventive Services Initiative
Jul 4, 2020·Human Brain Mapping·Janna Marie Bas-HoogendamUNKNOWN ENIGMA-Anxiety Working Group
Oct 31, 2018·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Lance M RappaportJohn M Hettema
May 5, 2017·Nature Reviews. Disease Primers·Michelle G CraskeHans-Ulrich Wittchen
Sep 18, 2020·Behavior Genetics·Aimee L ThomasMarissa A Ehringer
Feb 6, 2017·Clinical Epigenetics·Mihoko Shimada-SugimotoTsukasa Sasaki
Mar 3, 2020·The American Journal of Psychiatry·Ned H Kalin
Oct 10, 2020·Journal of Autism and Developmental Disorders·Christina A MartinNicole J Rinehart
Feb 10, 2021·Psychological Medicine·Helga AskHeike Weber
Feb 2, 2021·Scandinavian Journal of Child and Adolescent Psychiatry and Psychology·Krister Westlye FjermestadGro Janne Henningsen Wergeland
Feb 13, 2021·Translational Psychiatry·Simone M E SchopmanNeeltje M Batelaan
Apr 27, 2021·The American Journal of Psychiatry·Chad M SylvesterChristopher D Smyser
Aug 28, 2021·Journal of Affective Disorders·Sandra J WeissKristina M Deligiannidis
Nov 2, 2021·Child Psychiatry and Human Development·Colleen Stiles-ShieldsNiranjan S Karnik

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