Genetics of apolipoprotein B and apolipoprotein AI and premature coronary artery disease

Journal of Internal Medicine
A ZambonJ D Brunzell

Abstract

Increased low-density lipoprotein (LDL) and decreased high-density lipoprotein cholesterol (HDL-C) predict premature coronary artery disease, as do elevated levels of apolipoprotein B or reduced levels of apolipoprotein AI. Probands were studied of families with common genetic forms of dyslipidaemia to determine if apo B or apo AI define genetic groups and if apo B or apo AI levels relate to premature coronary artery disease risk. Elevated apo B was characteristic of familial hypercholesterolaemia, familial combined hyperlipidaemia (FCHL), and was seen in individuals with elevated Lp(a). Normal apo B levels were seen in familial hypertriglyceridaemia and in 'coronary artery disease with low-HDL cholesterol'. Apo AI levels tended to be low in FCHL and were decreased in 'coronary disease with low-HDL cholesterol'. In familial hypertriglyceraemia, even though HDL-C levels were low, normal apo AI and apo B levels were seen in the absence of premature coronary artery disease. Therefore, in genetic dyslipidaemias elevated apo B levels and reduced apo AI levels (or increased apo B/AI ratio) differ and predict premature coronary artery disease.

References

Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Feb 1, 1980·European Journal of Clinical Investigation·A ChaitJ D Brunzell
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
Mar 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·D L RainwaterJ L VandeBerg
Apr 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J E HokansonJ D Brunzell
Nov 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G P JarvikE Wijsman
Apr 4, 1998·The American Journal of Cardiology·M A AustinK L Edwards
Aug 4, 1999·Current Opinion in Lipidology·H H Hobbs, A L White
Aug 15, 2000·Molecular and Cellular Biochemistry·R A Srivastava, N Srivastava
Apr 17, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J Q PurnellJ D Brunzell
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Mario J VeerkampAnton F H Stalenhoef
Mar 18, 2003·Journal of Lipid Research·Samir S DeebJohn D Brunzell
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Roshni R SingarajaMichael R Hayden
Aug 24, 2004·American Journal of Epidemiology·Melissa A AustinSteve E Humphries
Nov 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Lars LindJohan Sundström

❮ Previous
Next ❯

Citations

Feb 10, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Annemart KoornneefPavlina Konstantinova
Sep 7, 2007·The New England Journal of Medicine·John D Brunzell
Mar 12, 2009·European Heart Journal·Franz WiesbauerMartin Schillinger
Oct 22, 2008·Journal of Lipid Research·Noelle B VargasGerald M Wilson
Mar 7, 2012·The Medical Clinics of North America·Payal Kohli, Christopher P Cannon
Dec 3, 2010·Journal of Clinical Lipidology·Leila ChaychiErnest J Schaefer
Aug 1, 2018·European Journal of Clinical Investigation·Max-Paul WinterGeorg Goliasch
Jun 9, 2007·Current Opinion in Cardiology·Göran Walldius, Ingmar Jungner
Jan 27, 2009·Clinical Chemistry·John H ContoisUNKNOWN AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.