Genetics of asthma and hay fever in Australian twins

The American Review of Respiratory Disease
D L DuffyJ D Mathews


The occurrence of self-reported asthma/wheezing and hay fever among 3,808 pairs of twins from the Australian National Health and Medical Research Council Twin Registry was examined for evidence of genetic transmission by path analytic methods. The cumulative prevalence of asthma or wheezing was 13.2% and of hay fever, 32%. There were significant correlations in liability to reported disease among twins, and these were higher in monozygotic twins (MZ) (r = 0.65) than in dizygotic twins (DZ) (r = 0.25), and in male MZ twins (r = 0.75) compared with female MZ twins (r = 0.60). Analysis under the assumptions of the classic twin model suggested that there were genetic factors common to asthma and hay fever, with a correlation in genetic liability to the traits of 0.52 for men and 0.65 for women. These genes acted substantially in a nonadditive fashion in men but not in women. As the genetic correlation was significantly less than unity, this implied additional genetic factors influencing either or both diseases individually. The estimated heritability of these diseases was 60 to 70% in this population. Environmental causes of both diseases also were correlated (r = 0.53 for men and 0.33 for women). Cigarette smoking was only weakly ...Continue Reading


Dec 10, 2008·Current Allergy and Asthma Reports·Saffron A G Willis-OwenMiriam F Moffatt
Jan 24, 2002·Clinical Reviews in Allergy & Immunology·R Michael Sly
Dec 29, 2007·Clinical Reviews in Allergy & Immunology·Yin-Hsiu ChienBor-Luen Chiang
May 29, 1993·Lancet·A M Macdonald
May 10, 2005·Immunology and Allergy Clinics of North America·Christina M Abraham, Dennis R Ownby
May 10, 2005·Immunology and Allergy Clinics of North America·Wanda Phipatanakul
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Erika von Mutius
Mar 3, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Min WangLi-Sheng Yu
Jun 15, 2005·Pulmonary Pharmacology & Therapeutics·Stephen T HolgateJohn W Holloway
Apr 10, 2003·Trends in Genetics : TIG·William O C Cookson
Apr 10, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Einat YaariEitan Kerem
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L Borish
Dec 1, 1992·The Journal of Laryngology and Otology·A Drake-Lee
Jul 13, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E P Sarafino
Dec 21, 2002·Immunological Reviews·William O C Cookson
Dec 19, 2008·European Journal of Human Genetics : EJHG·Craig C TeerlinkLisa A Cannon-Albright
May 15, 2004·Nature Reviews. Genetics·Marsha Wills-Karp, Susan L Ewart
Dec 2, 2004·Nature Reviews. Immunology·William O C Cookson
Dec 8, 2005·European Journal of Human Genetics : EJHG·Ulla ChristensenAnders D Børglum
Mar 29, 2006·The Pharmacogenomics Journal·S T WeissK G Tantisira
Aug 24, 1999·Clinical and Experimental Dermatology·V Bataille
Aug 29, 2002·Clinical and Experimental Immunology·M N HylkemaW Timens
Sep 1, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·A Thomas McLellan
Feb 26, 2010·Biodemography and Social Biology·Edith Chen, Wei-Jun Jean Yeung
Sep 28, 2002·Current Opinion in Pediatrics·Kelly D Stone
Sep 26, 2003·Current Opinion in Pediatrics·Kelly D Stone
Jun 15, 2007·Pharmacogenetics and Genomics·Miles D ThompsonKatherine A Siminovitch
Nov 1, 1995·Allergy·C I PanhuysenE R Bleecker
Feb 1, 1993·Journal of Paediatrics and Child Health·L I Landau
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andrew J Sandford
Aug 1, 1995·Archives of Disease in Childhood·E P Sarafino, J Goldfedder
Oct 20, 2006·Occupational and Environmental Medicine·F Castro-GinerM Kogevinas
Jan 1, 1997·Thorax·E HuovinenM Koskenvuo
Dec 26, 2002·Annual Review of Immunology·Hannah J GouldLyn Smurthwaite
Dec 22, 2007·Dementia and Geriatric Cognitive Disorders·Ulrika K ErikssonNancy L Pedersen


Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·William W Busse
Mar 1, 1989·The American Review of Respiratory Disease·W P McWhorterR A Kaslow
Jun 1, 1988·Thorax·P Burney
Mar 1, 1988·Chest·A S Buist
Jan 1, 1988·Behavior Genetics·L J Eaves
Aug 1, 1971·Acta Allergologica·M L Edfors-Lubs
Jun 1, 1983·Australian and New Zealand Journal of Medicine·C Mitchell, J Miles

Related Concepts

Monozygotic Twins
Diseases in Twins
Hay Fever
Two-Parameter Models
Twins, Dizygotic

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.