Genetics of biologically based psychological differences

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Hannah SallisMarcus R Munafò

Abstract

In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization.This article is part of the theme issue 'Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.

References

Jun 1, 1992·Journal of Personality·E C Tupes, R E Christal
Apr 1, 1994·Current Opinion in Neurobiology·C R Cloninger
Apr 1, 1997·Journal of Personality and Social Psychology·D Finkel, M McGue
Mar 3, 1999·Twin Research : the Official Journal of the International Society for Twin Studies·L J EavesN G Martin
Jul 10, 2002·Psychological Medicine·A FanousK S Kendler
Jul 26, 2002·Briefings in Bioinformatics·Frühling V Rijsdijk, Pak C Sham
Mar 19, 2003·Lancet·Helen M ColhounGeorge Davey Smith
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
May 10, 2005·BMJ : British Medical Journal·George Davey Smith, Shah Ebrahim
Mar 16, 2006·Proceedings. Biological Sciences·Daniel Nettle, Helen Clegg
Dec 1, 2007·Journal of Drug Education·John M MalouffNicola S Schutte
Oct 30, 2008·Molecular Psychiatry·A TerraccianoP T Costa
May 20, 2009·The American Psychologist·Benjamin B Lahey
May 22, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Livia VeselkaPhilip Anthony Vernon
Aug 6, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·J Philippe RushtonClaudio Barbaranelli
Sep 18, 2010·Current Psychiatry Reports·Falk W Lohoff
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Dec 22, 2010·Molecular Psychiatry·M H M de MoorD I Boomsma
Feb 5, 2011·Nature Protocols·Geraldine M ClarkeKrina T Zondervan
Apr 27, 2012·Journal of the National Cancer Institute·Marcus R MunafòGeorge Davey Smith
May 26, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michelle LucianoIan J Deary
Jul 27, 2012·Translational Psychiatry·S K ServiceN B Freimer
Aug 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Lannie Ligthart, Dorret I Boomsma
Aug 11, 2012·Journal of Research in Personality·Christopher J HopwoodM Brent Donnellan
Dec 12, 2012·American Journal of Human Genetics·Doug SpeedDavid J Balding
May 10, 2013·Frontiers in Genetics·Harold T BaeThomas T Perls
May 25, 2013·Clinical Psychology Review·Johan OrmelAlbertine J Oldehinkel
Jun 13, 2013·Methods in Molecular Biology·Jian YangPeter M Visscher
Aug 2, 2013·Journal of Human Genetics·Han-Na KimHyung-Lae Kim
Aug 13, 2013·Nature Genetics·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics ConsortiumUNKNOWN International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
May 2, 2014·Biological Psychiatry·Marcus R Munafò, Jonathan Flint
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Jul 30, 2014·Human Molecular Genetics·George Davey Smith, Gibran Hemani

❮ Previous
Next ❯

Citations

Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I TrofimovaJ Uher
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jana UherLouis A Schmidt
Apr 24, 2020·New Directions for Child and Adolescent Development·Olga V Burenkova, Aleksei A Podturkin
Aug 12, 2021·CNS Spectrums·Clara MarincowitzDan J Stein

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
chips
chip

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Vladimir Rusalov
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
C Robert Cloninger, Igor Zwir
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Irina TrofimovaJana Uher
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Lars FardeSimon Cervenka
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
T W Robbins
© 2022 Meta ULC. All rights reserved