Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Jonathan A MitchellStruan F A Grant

Abstract

We aimed to determine if adult bone mineral density (BMD) susceptibility loci were associated with pediatric bone mass and density, and if sex and pubertal stage influenced any association. We analyzed prospective areal BMD (aBMD) and bone mineral content (BMC) data from the Bone Mineral Density in Childhood Study (n = 603, European ancestry, 54% female). Linear mixed models were used to assess if 77 single-nucleotide polymorphisms (SNPs) near known adult BMD susceptibility loci interacted with sex and pubertal stage to influence the aBMD/BMC; adjusting for age, BMI, physical activity, and dietary calcium. The strongest main association was observed between an SNP near C7orf58 and distal radius aBMD. However, this association had a significant sex • SNP interaction, revealing a significant association only in females (b = -0.32, p = 1.8 × 10(-6)). Furthermore, the C12orf23 locus had significant interactions with both sex and pubertal stage, revealing associations in females during Tanner stage I for total hip aBMD (b = 0.24, p = 0.001) and femoral neck aBMD (b = 0.27, p = 3.0 × 10(-5)). In contrast, the sex • SNP interactions for loci near LRP5 and WNT16 uncovered associations that were only in males for total body less head BM...Continue Reading

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Citations

Nov 18, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan A MitchellBabette S Zemel
Nov 7, 2016·The Journal of Pediatrics·Catherine M GordonKaren K Winer
Dec 13, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yi YangGraeme Jones
Jan 15, 2019·The Physician and Sportsmedicine·William R TebarDiego G D Christofaro
Sep 4, 2019·Medicine and Science in Sports and Exercise·Irene Rodríguez-GómezIgnacio Ara
Jun 24, 2020·The Journal of Gene Medicine·Nima Montazeri-NajafabadyRajeeh Mohammadian Amiri
Aug 29, 2020·Pediatric Radiology·Hedieh KhalatbariMarguerite T Parisi
Feb 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alessandra ChesiStruan Fa Grant
Oct 27, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Diana L CousminerStruan Fa Grant
May 12, 2020·Frontiers in Endocrinology·Danilo FintiniMelania Manco
Sep 1, 2016·BoneKEy Reports·Jonathan A MitchellAlessandra Chesi
Mar 30, 2018·Journal of Inherited Metabolic Disease·I Rodríguez-GómezI Ara
Mar 13, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan A MitchellStruan Fa Grant
May 14, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan A MitchellBabette S Zemel
Jul 16, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shana E McCormackBabette S Zemel
Jan 16, 2020·Medicine and Science in Sports and Exercise·Irene Rodríguez-GómezIgnacio Ara
Mar 21, 2020·Frontiers in Endocrinology·Alexandra E Kralick, Babette S Zemel
Jun 11, 2020·Frontiers of Medicine·Xiaowei Zhu, Houfeng Zheng
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Nov 5, 2020·The Journal of Sports Medicine and Physical Fitness·Paulo F de Almeida-NetoBreno G Cabral
Oct 28, 2019·Human Heredity·Nima Montazeri-NajafabadyZahra Mirzai

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