Genetics of canine subvalvular aortic stenosis (SAS).

Canine Medicine and Genetics
Eric S Ontiveros, Joshua A Stern

Abstract

Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands.

References

Nov 1, 1992·Veterinary Surgery : VS·K Linn, E C Orton
Aug 1, 1968·Circulation Research·D F Patterson
Nov 1, 1994·Journal of Veterinary Internal Medicine·R D KienleP D Pion
Jul 1, 1993·European Journal of Pediatrics·M C DigilioB Dallapiccola
Mar 1, 1997·The Journal of Small Animal Practice·A Tidholm
Feb 11, 2000·Journal of the American Veterinary Medical Association·E C OrtonE Monnet
Sep 21, 2000·Journal of the American Animal Hospital Association·R L Pyle
Oct 2, 2004·Journal of the American Veterinary Medical Association·David A NelsonGalen Pahl
Apr 23, 2005·Cardiology in the Young·Robert M FreedomWilliam G Williams
Aug 27, 2005·Journal of the American Veterinary Medical Association·Kathryn M MeursJohn D Bonagura
Dec 5, 2006·The Journal of Thoracic and Cardiovascular Surgery·Saulat H FatimiRizwan Ahmad
Aug 29, 2007·The Journal of Thoracic and Cardiovascular Surgery·Gerardo PiacentiniMaria Cristina Digilio
Aug 8, 2008·The Journal of Small Animal Practice·M HöllmerJ Koch
Dec 1, 2000·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·C BussadoriC W Lombard
May 23, 2009·European Journal of Medical Genetics·Feng LiDenise A S Batista
May 22, 2010·Cellular and Molecular Life Sciences : CMLS·Boris StrilićEckhard Lammert
Mar 23, 2011·Journal of Veterinary Internal Medicine·P OliveiraC Bussadori
Mar 16, 2012·The Journal of Small Animal Practice·J A SternL B Lehmkuhl
May 15, 2012·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Mandi E KlemanJoseph A Paolillo
May 31, 2012·The Veterinary Record·S B Reist-MartiS Rieder
Mar 7, 2014·Journal of Veterinary Internal Medicine·B D EasonA H Tobias
Mar 16, 2019·Frontiers in Veterinary Science·Eric S OntiverosJoshua A Stern
Sep 26, 2020·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·K T SykesR C Fries

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