Genetics of chemical carcinogenesis. 1. Bidirectional selective breeding of susceptible and resistant lines of mice to two-stage skin carcinogenesis

Carcinogenesis
C BangraziG Biozzi

Abstract

Six generations of a bidirectional selective breeding model for producing lines of mice susceptible (Car-S) and resistant (Car-R) to two-stage skin carcinogenesis are described. Initiation was with 9,10-dimethyl-1,2-benzanthracene (DMBA single application), and promotion with 12-O-tetradecanoyl-phorbol-13-acetate (TPA twice weekly). The selective breeding was initiated with a highly genetically polymorph foundation population, produced by the intercrossing of eight inbred mouse strains. The Car-S line was produced by assortative mating of the mice presenting the largest number of tumors induced by low DMBA and TPA doses, the Car-R line by mating tumorless mice or mice showing the smallest number of tumors induced by large DMBA and TPA doses. The character investigated was expressed as per cent tumor incidence and as tumor multiplicity per mouse. The mean heritability of the susceptibility character for the two first generations was 0.84 for tumor incidence and 1.3 for tumor multiplicity; these values decreased to 0.53 and 0.44 respectively for the two consecutive generations. The heritability of the resistance character maintained a constant value of 0.29 +/- 0.04 for tumor incidence, and 0.53 +/- 0.08 for tumor multiplicity. T...Continue Reading

Citations

Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Anna SaranTommaso A Dragani
Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Jun 1, 2005·Cancer Letters·Simonetta Pazzaglia
Jun 22, 2010·Molecular Carcinogenesis·Kyoko FujiwaraHiroki Nagase
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·T A DraganiI Nakashima
Aug 31, 2002·Molecular Carcinogenesis·Mariana C SternClaudio J Conti
Dec 5, 2000·Oncogene·G ManentiT A Dragani
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Shin AkakuraIrwin H Gelman
Nov 9, 2018·Oncology Letters·Kyoko FujiwaraHiroki Nagase
Mar 30, 2021·Experimental Animals·Kazuhiro OkumuraYuichi Wakabayashi

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