Genetics of coeliac disease

QJM : Monthly Journal of the Association of Physicians
Richard S Houlston, D Ford

Abstract

Coeliac disease is one of the most common gastrointestinal disorders. The clinical features of the disease are protean, possibly due to heterogeneity. A familial basis for coeliac disease is well recognized, and although a strong HLA association is seen, this cannot entirely account for the increased risk seen in relatives of affected cases. A gene (or genes) at an HLA-unlinked locus also participates in causing coeliac disease and is likely to be a stronger determinant of disease susceptibility than the HLA locus. Such a gene (or genes) could theoretically act either additively or multiplicatively in conjunction with HLA. However, the familial risks seen in siblings and monozygotic twins are most parsimonious with a multiplicative model. Without evidence for a particular HLA-unlinked gene, and because no genetic model can be reliably ascribed to the non-HLA-linked locus, identifying causative non-linked HLA genes is likely to be through a genome-wide linkage search using non-parametric methods.

Citations

Nov 29, 2011·Nature Genetics·Peter BroderickRichard S Houlston
May 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Sandya LiyanarachchiAlbert de la Chapelle
Nov 28, 2012·Human Molecular Genetics·Marc HenrionRichard S Houlston
Sep 29, 2012·Journal of the National Cancer Institute·Evropi TheodoratouJulian Little
Oct 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·L Peña-QuintanaF Sánchez-García
Mar 9, 2007·Gut·Mathieu BourgeyLucia Sacchetti
Mar 4, 2000·Journal of Medical Genetics·R S Houlston, I P Tomlinson
Feb 21, 2014·Journal of Pediatric Gastroenterology and Nutrition·Amaia Jauregi-MiguelJose Ramon Bilbao
Oct 19, 2007·Genes and Immunity·Y C DingS L Neuhausen
Jan 12, 2010·Nature Genetics·Dalemari Crowther-SwanepoelRichard S Houlston
Jan 22, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Sean G BoynesC Richard Bennett
Oct 10, 2015·International Journal of Epidemiology·Zahra MontazeriJulian Little
Jul 3, 1998·Gastroenterology·A Godkin, D Jewell
Jun 5, 2015·Biosensors & Bioelectronics·Hamdi JodaCiara K O Sullivan
Jan 1, 2010·The Journal of Clinical Pediatric Dentistry·Soliman OudaSumer Alaki
Apr 1, 2015·PloS One·Marc Y R HenrionRichard S Houlston
Jan 5, 2002·The American Journal of Gastroenterology·M J van BelzenC Wijmenga
Dec 1, 2006·Genes and Immunity·C P GarnerS L Neuhausen
Feb 20, 2003·The American Journal of Gastroenterology·Linda BookSusan L Neuhausen
Jul 19, 2002·American Journal of Medical Genetics·Susan L NeuhausenJohn J Zone
Feb 15, 2000·Scandinavian Journal of Gastroenterology·M A AldersleyP D Howdle
Oct 19, 2002·The American Journal of Gastroenterology·F Biagi, G R Corazza
Jan 18, 2018·BMC Public Health·Morten ValbergOdd O Aalen
Dec 29, 2000·Journal of the American Geriatrics Society·V TaiS O'Keefe
Apr 20, 2000·American Journal of Veterinary Research·O A GardenR M Batt
Apr 11, 2013·British Journal of Cancer·V Enciso-MoraR S Houlston
Dec 11, 2019·Minerva gastroenterologica e dietologica·Federico BiagiGiacomo Biagi
Dec 14, 2001·European Journal of Gastroenterology & Hepatology·S PopatR S Houlston
Nov 1, 2002·Scandinavian Journal of Gastroenterology. Supplement·P J WahabC J J Mulder
Mar 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sandya LiyanarachchiAlbert de la Chapelle
Nov 16, 2004·Arquivos De Gastroenterologia·Shirley Ramos da Rosa UtiyamaLorete Maria da Silva Kotze
Sep 1, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Miguel Ángel López CasadoMaria Isabel Torres

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