Genetics of common forms of heart failure: challenges and potential solutions

Current Opinion in Cardiology
Christoph D RauYibin Wang

Abstract

In contrast to many other human diseases, the use of genome-wide association studies (GWAS) to identify genes for heart failure (HF) has had limited success. We will discuss the underlying challenges as well as potential new approaches to understanding the genetics of common forms of HF. Recent research using intermediate phenotypes, more detailed and quantitative stratification of HF symptoms, founder populations and novel animal models has begun to allow researchers to make headway toward explaining the genetics underlying HF using GWAS techniques. By expanding analyses of HF to improved clinical traits, additional HF classifications and innovative model systems, the intractability of human HF GWAS should be ameliorated significantly.

References

Jan 5, 2000·American Heart Journal·H M KrumholzR I Horwitz
Mar 20, 2003·European Heart Journal·L SwanW S Hillis
Oct 2, 2003·Human Molecular Genetics·Philippe Le CorvoisierHoward A Rockman
Aug 3, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ferrin C WheelerDouglas A Marchuk
Jul 11, 2007·The Journal of Heredity·Ute PhilippOttmar Distl
Apr 30, 2008·Genomics·Petra WernerPaula S Henthorn
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Ramachandran S VasanStefan Blankenberg
Sep 19, 2009·PLoS Genetics·Ferrin C WheelerDouglas A Marchuk
Oct 8, 2009·Circulation. Heart Failure·Richard D Patten, Monica R Hall-Porter
Feb 4, 2010·Circulation. Cardiovascular Genetics·Thomas P CappolaGerald W Dorn
Mar 10, 2010·Disease Models & Mechanisms·Ross Breckenridge
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Feb 26, 2011·Clinical and Translational Science·Afshin ParsaStephen B Liggett
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
Mar 23, 2011·Nature Reviews. Genetics·Esther E CreemersYigal M Pinto
Sep 6, 2011·Nature Methods·Christoph LippertDavid Heckerman
Sep 14, 2011·Journal of Molecular and Cellular Cardiology·Sanne de JongPeter R Luijten
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 16, 2013·European Heart Journal·Benjamin MederHugo A Katus
Dec 7, 2014·Circulation. Cardiovascular Genetics·Christoph D RauAldons J Lusis

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Citations

Nov 23, 2016·Journal of Medical Genetics·Xianchi Li, Peiying Zhang
Nov 26, 2016·Heart Failure Clinics·Jeremy A Mazurek, Mariell Jessup
Dec 28, 2018·Circulation·Krishna G AragamUNKNOWN GRADE Investigators
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Silje Madeleine KalstøIngrid E Christophersen
Jun 5, 2020·Circulation Research·Christoph D RauYibin Wang
Jun 13, 2020·Circulation Research·Wilson Lek Wen TanUNKNOWN CHARGE-Heart Failure Working Group, CHARGE-EchoGen Consortium
Mar 12, 2019·Npj Regenerative Medicine·Ekaterina SalimovaNadia A Rosenthal
Jun 19, 2018·Cardiovascular Research·Maaike Yldau van der EndePim van der Harst
Jun 19, 2018·Frontiers in Cardiovascular Medicine·Christoph PaoneSteffen Just
Aug 13, 2020·Current Heart Failure Reports·Jan D LanzerJulio Saez-Rodriguez

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