Genetics of deafness in India

Indian Journal of Pediatrics
Manju GhoshMadhulika Kabra

Abstract

Linkage analysis in families with hereditary hearing loss have revealed a plethora of chromosomal locations linked to deafness reflecting the extreme heterogeneity of the disorder. 40 of the genes contained within these loci have been mapped lending an insight into the diverse molecules operating in the inner ear and the remarkable complexity of the cellular and molecular processes involved in the transucdation of sound in the auditory system. Among this diversity, Connexin 26 has been found to be the most common cause of deafness the world around. The authors review here the prevalence of this gene in the Indian population as found in their study, together with other deafness genes segregating non-syndromic deafness, accounting for approximately 40% of all cases. This indicates there are several more to be identified yet. Knowledge of the genetic cause of deafness in our families is important for accurate genetic counseling and early diagnosis for timely intervention and treatment options.

References

Nov 20, 1998·The New England Journal of Medicine·R J MorellT B Friedman
Jun 9, 2001·American Journal of Human Genetics·Z M AhmedE R Wilcox
Nov 9, 2001·Annual Review of Genetics·C PetitJ P Hardelin
Nov 10, 2001·Annual Review of Genomics and Human Genetics·C Petit
May 17, 2002·Human Molecular Genetics·Cynthia C Morton
Jul 2, 2003·American Journal of Medical Genetics. Part a·Manjula MaheshwariP S N Menon
Aug 19, 2003·Ear and Hearing·Lut Van LaerGuy Van Camp
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Thomas B Friedman, Andrew J Griffith

❮ Previous
Next ❯

Citations

Jan 1, 2010·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Koumudi GodboleG R Chandak
Nov 6, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Y BajajM Bitner-Glindzicz
Apr 27, 2005·International Journal of Pediatric Otorhinolaryngology·Josef Finsterer, Johannes Fellinger
Jul 18, 2015·Genetic Testing and Molecular Biomarkers·Denise YanXue Zhong Liu
Feb 23, 2021·Intractable & Rare Diseases Research·Smita HegdeRudregouda Bulgouda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.