PMID: 11918459Mar 29, 2002Paper

Genetics of epilepsy

Journal of Child Neurology
L James Willmore, Yuto Ueda

Abstract

Understanding the molecular biology of epilepsy is a challenge for modern science. Epilepsy results from alternations in fundamental mechanisms of brain and membrane function. Although an understanding of the mode of inheritance and the etiology of genetic epilepsy syndromes forms the basis for genetic counseling, the development of specific therapies will come from knowing the basic mechanisms of epilepsy. Defining the genes causing epilepsy requires an unambiguous definition of seizure phenotype, along with the stability of that trait, an unremitting clinical course, and an abundance of clinical material. This article reviews the task of defining the genetics of epilepsy and discusses genetic methodology, idiopathic generalized and localization-related partial epilepsies, neuronal migration disorders, progressive myoclonus epilepsies, molecular biology of epileptogenesis, and future research.

References

Aug 1, 1992·European Journal of Pediatrics·F VigevanoP Lucchini
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E LehesjokiA de la Chapelle
Jan 1, 1991·American Journal of Medical Genetics·K A WeissbeckerM A Spence
Sep 14, 1990·Science·J GuastellaB I Kanner
Jul 1, 1990·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K WatanabeM Maehara
Feb 1, 1990·Annals of Neurology·K B Nelson, J H Ellenberg
May 1, 1989·Annals of Neurology·C P Panayiotopoulos, T Obeid
Sep 1, 1988·American Journal of Medical Genetics·D A GreenbergP I Terasaki
Jun 1, 1985·Annals of Neurology·S DiMauroD C DeVivo
Jul 1, 1984·American Journal of Medical Genetics·J ZonanaB Strimling
Jun 1, 1995·Neuropediatrics·W B Dobyns, C L Truwit
Dec 1, 1995·Epilepsia·P LoiseauJ M Pédespan
May 1, 1995·Nature Genetics·R OttmanM L Scheuer
Sep 1, 1993·Trends in Neurosciences·Y KanaiM A Hediger
Feb 1, 1995·Brain : a Journal of Neurology·I E SchefferF Cendes
Feb 26, 1994·Lancet·I E SchefferJ I Manson
Nov 1, 1994·Archives of Neurology·S F BerkovicG A Nicholson
Jan 1, 1994·Neurology·P R HuttenlocherS Mojtahedi
Jul 1, 1995·Human Molecular Genetics·F ZaraM Pandolfo
Sep 1, 1995·Human Molecular Genetics·J M SerratosaR S Sparkes
Aug 1, 1996·Neurology·W B DobynsC L Truwit
Aug 1, 1996·Annals of Neurology·S F BerkovicJ L Hopper

❮ Previous
Next ❯

Citations

Sep 8, 2012·Epilepsy Research and Treatment·Katherine C NickelsElaine C Wirrell
Jun 1, 2010·Continuum : Lifelong Learning in Neurology·Elaine Wirrell, Katherine C Nickels

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Neurology and Neurosurgery
P M Callenbach, O F Brouwer
Continuum : Lifelong Learning in Neurology
Elaine Wirrell, Katherine C Nickels
Expert Opinion on Pharmacotherapy
Ahmad Beydoun, Joseph D'Souza
Jornal de pediatria
Iscia Lopes-Cendes
© 2022 Meta ULC. All rights reserved