Genetics of Hypercoagulable and Hypocoagulable States

Neurosurgery Clinics of North America
Daulath SinghHanh P Mai

Abstract

Hemostasis is the normal process of blood coagulation in vivo to stop pathologic bleeding. Virchow triad includes venous stasis, hypercoagulability, and vascular injury. Natural anticoagulants include protein C, protein S, and antithrombin. Factor V Leiden is the most common inherited thrombophilia, followed by prothrombin gene mutation. All inherited thrombophilias are passed down in an autosomal dominant fashion. Patients harboring the antiphospholipid antibodies have an increased risk for thrombosis. von Willebrand disease is the most common inherited bleeding disorder; the pattern of inheritance is autosomal. Hemophilia A and B are the only hereditary bleeding disorders inherited in a sex-linked recessive pattern.

Citations

Jan 30, 2021·Journal of Translational Internal Medicine·Eray Yıldız, Funda Müşerref Türkmen
Jun 8, 2021·Journal of Blood Medicine·Marjan AlidoostMohammad A Hossain

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Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

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