Apr 25, 2012

Genetics of longevity. data from the studies on Sicilian centenarians

Immunity & Ageing : I & a
Carmela Rita BalistreriGiuseppina Colonna-Romano

Abstract

The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and unsuccessful ageing". They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer. Thus, particular attention has been centered on their genetic background and immune system. In this review, we report our data gathered for over 10 years in Sicilian centenarians. Based on results obtained, we suggest longevity as the result of an optimal performance of immune system and an over-expression of anti-inflammatory sequence variants of immune/inflammatory genes. However, as well known, genetic, epigenetic, stochastic and environmental factors seem to have a crucial role in ageing and longevity. Epigenetics is associated with ageing, as demonstrated in many studies. In particular, ageing is associated with a global loss of methylation s...Continue Reading

  • References69
  • Citations24

Citations

Mentioned in this Paper

Immune System
Protein Methylation
Anti-Inflammatory Agents
Cardiovascular Diseases
Study of Epigenetics
Methylation
Aging
Exogenous Factors
Entire Immune System
Public Health Domain

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