Genetics of mammalian reproduction: modeling the end of the germline.

Annual Review of Physiology
Martin M Matzuk, Kathleen H Burns

Abstract

Our understanding of reproduction and early embryonic development has directly enabled our manipulation of the mouse genome for tests of gene function in vivo. In this review, we reflect on the 30 years of work that followed this singular accomplishment. We profile murine models that have given us memorable insights into fundamental processes of male and female gametogenesis and the earliest phases of embryonic life reliant on oocyte-transmitted maternal gene products. We highlight intercellular endocrine and paracrine communications essential to gamete development as well as mechanisms essential for passing the genome, with integrity and appropriate epigenetic marks, on to the next generation. Finally, we reflect on the future of reproductive biology: how advances in clinical genetics will provide special opportunities to understand which reproductive processes are affected by genetic lesions and which may allow mutations to originate.

References

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Citations

Jan 23, 2014·Reproductive Biomedicine Online·Piraye Yurttas BeimTina T Hu-Seliger
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jia PengMartin M Matzuk
Dec 26, 2013·Stem Cells and Development·Maureen L Condic
Oct 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sreelaja NairFrancisco Pelegri
Sep 24, 2014·Reproductive Biomedicine Online·Dora Janeth FonsecaPaul Laissue
Mar 10, 2016·Asian-Australasian Journal of Animal Sciences·Fernanda Cavallari de CastroClaudia Lima Verde Leal
Mar 23, 2017·Endocrinology·Diana MonsivaisMartin M Matzuk
Apr 13, 2018·Nature Reviews. Molecular Cell Biology·Charles J David, Joan Massagué
Feb 2, 2018·Scientific Reports·Barnali BiswasPamela Stanley
Sep 8, 2016·The Journal of Clinical Endocrinology and Metabolism·Justine BouillyNadine Binart
May 15, 2020·Biology of Reproduction·Leah E SimonFrancesca E Duncan
Feb 20, 2015·Reproduction, Fertility, and Development·Kun Zhang, George W Smith
Jan 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Diana MonsivaisMartin M Matzuk
May 4, 2017·BMC Medical Genetics·Se Ra SungSung Han Shim
Jan 21, 2014·Molecular BioSystems·Hui HeRan Huo

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Methods Mentioned

BETA
transgenic
targeted mutations
X-ray
contraception

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