Abstract
Genetics of migraine has recently undergone a major shift, moving in the space of a few years from having only a few known genes for rare Mendelian forms to 47 known common variant loci affecting the susceptibility of the common forms of migraine. This has largely been achieved by rapidly increasing sample sizes for genomewide association studies (GWAS), soon to be followed by the first wave of large-scale exome-sequencing studies. The large number of detected loci, chief among them TRPM8, PRDM16, and LRP1, have enabled a number of in silico analyses, which have shed light on the functional and tissue-level aspects of the common risk variants for migraine, including evidence for involvement of both vascular and neuronal mechanisms. Polygenic risk scores and other measures of genetic variance based on GWAS information are further opening the door to dissecting pharmacogenetics, functional etiology, and comorbidity. Heritability-based analyses are demonstrating strong links between migraine and other neuropsychiatric disorders and brain phenotypes, highlighting genetic links between migraine and major depressive disorder and attention-deficit hyperactivity disorder, among others. These recent successes in migraine genetics are st...Continue Reading
Citations
Nov 20, 2018·Expert Opinion on Therapeutic Targets·Innocenzo RaineroElisa Rubino
Jan 20, 2019·Headache·Mario F P PeresGiancarlo Lucchetti
Mar 30, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Piero BarbantiGabriella Egeo
Jul 25, 2019·International Journal of Molecular Sciences·Yasunori TakayamaMakoto Tominaga
Sep 13, 2019·Current Pain and Headache Reports·Raquel Gil-Gouveia, Isabel Pavão Martins
Feb 15, 2020·Expert Opinion on Therapeutic Targets·Innocenzo RaineroElisa Rubino
May 31, 2019·Pain·Daniel BullockMichael Costigan
Dec 12, 2019·Frontiers in Neurology·Mengmeng LiWeihong Lin
Mar 5, 2020·Journal of Neurology·Anish Bahra
Jul 22, 2018·Current Medicinal Chemistry·Innocenzo RaineroElisa Rubino
Jan 13, 2019·The Journal of Headache and Pain·Arn M J M van den MaagdenbergVerneri Anttila
Mar 27, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Halit Necmi UçarEmine Tekin
Oct 31, 2020·Headache·Hayrunnisa BolayBetül Baykan
Feb 3, 2021·Children·David ChampionJohn Hopper
Oct 8, 2020·Pain·Anne-Sophie WattiezAndrew F Russo