PMID: 2493303Jan 14, 1989Paper

Genetics of obesity in adult adoptees and their biological siblings

BMJ : British Medical Journal
T I SørensenF Schulsinger

Abstract

An adoption study of genetic effects on obesity in adulthood was carried out in which adoptees separated from their natural parents very early in life were compared with their biological full and half siblings reared by their natural parents. The adoptees represented four groups who by sampling from a larger population were categorised as either thin, medium weight, overweight, or obese. Weight and height were obtained for 115 full siblings of 57 adoptees and for 850 half siblings of 341 adoptees. In full siblings body mass index (kg/m2) significantly increased with weight of the adoptees. Body mass index of the half siblings showed a steady but weaker increase across the four weight groups of adoptees. There were no significant interactions with sex of the adoptees, sex of the siblings, or (for the half siblings) sex of the common parent. In contrast with the findings in half siblings and (previously) the natural parents there was a striking, significant increase in body mass index between full siblings of overweight and obese adoptees. The degree of fatness in adults living in the same environment appears to be influenced by genetic factors independent of sex, which may include polygenic as well as major gene effects on obesity.

References

Oct 1, 1977·Annals of Human Genetics·A HartzA A Rimm
Jun 1, 1977·Journal of Chronic Diseases·S Sonne-Holm, T I Sorensen
Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Jul 1, 1976·The New England Journal of Medicine·E CharneyR Pratt
Mar 24, 1988·The New England Journal of Medicine·T I SørensenT W Teasdale
Aug 1, 1987·The American Journal of Psychiatry·R A PriceE Troughton
Dec 1, 1987·The American Journal of Clinical Nutrition·O E OwenM A Mozzoli
Jul 4, 1986·JAMA : the Journal of the American Medical Association·A J StunkardZ Hrubec
Feb 1, 1985·Current Problems in Pediatrics·S M Garn
Jan 23, 1986·The New England Journal of Medicine·A J StunkardF Schulsinger
Mar 1, 1983·Annals of Human Biology·R SavardA Tremblay
May 1, 1983·Poultry Science·J KochD Yeager
Aug 1, 1981·The American Journal of Clinical Nutrition·A J Stunkard, J M Albaum
Dec 1, 1981·The American Journal of Clinical Nutrition·A F RocheP Webb

❮ Previous
Next ❯

Citations

Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M FriedmanN Bahary
Sep 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D B WestR A Price
Jan 1, 1991·Behavior Genetics·R A Price, I I Gottesman
Jan 21, 2010·Behavior Genetics·Brett C HaberstickJohn K Hewitt
Apr 1, 1993·Physiology & Behavior·J M de Castro
Oct 10, 1992·Lancet
Jan 11, 1991·Addictive Behaviors·L H EpsteinR C Murdock
May 10, 2005·Hormones and Behavior·Aitziber AzurmendiJosé R Sánchez-Martín
Oct 9, 2002·Neuroscience and Biobehavioral Reviews·John M de Castro, Stephanie Plunkett
Apr 20, 2001·Nutrition·J M de Castro, S S Plunkett
Jul 1, 1994·Baillière's Clinical Endocrinology and Metabolism·P G Kopelman
Apr 3, 2012·Public Health Nutrition·Bernt J von ScholtenTine Jess
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S O'Rahilly, I S Farooqi
Sep 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C K Wells
Jul 8, 1999·Journal of Internal Medicine·S M Echwald
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K S Steinbeck
Apr 1, 1997·The British Journal of Nutrition·J M De Castro
Mar 1, 1997·The Proceedings of the Nutrition Society·J M De Castro
Sep 27, 2012·American Journal of Therapeutics·Joselyn RojasValmore Bermúdez
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen O'Rahilly, I Sadaf Farooqi
Jun 23, 1990·BMJ : British Medical Journal·T W TeasdaleA J Stunkard
Jul 9, 1999·Journal of Epidemiology and Community Health·H E HarrisS Clement
Jun 3, 2011·The Journal of Clinical Investigation·Shwetha Ramachandrappa, I Sadaf Farooqi
Aug 28, 2010·Biological Research for Nursing·Nuananong Seal
Jan 1, 1988·Journal of Personality Assessment·L D CohnG Stone
Aug 24, 2012·Disease Models & Mechanisms·Jonathan C K Wells
Dec 23, 2009·American Journal on Intellectual and Developmental Disabilities·Deborah A NapolitanoJillian Maynard Caliendo
Sep 24, 2004·The Journal of Psychology·Rob SandsChristine Armatas
Aug 27, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sadaf Farooqi
Jan 1, 1993·Genetic Epidemiology·A NirmalaD C Rao
Nov 26, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P RussoA Siani
Oct 27, 2009·Ageing Research Reviews·Stephen R Spindler
Mar 31, 2015·Cell·Agatha A van der Klaauw, I Sadaf Farooqi
Oct 7, 2015·Trends in Endocrinology and Metabolism : TEM·Alessandra Chesi, Struan F A Grant
Dec 13, 2002·American Journal of Human Genetics·Chuanhui DongR Arlen Price

❮ Previous
Next ❯

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