PMID: 9657845Jul 10, 1998Paper

Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation

Mammalian Genome : Official Journal of the International Mammalian Genome Society
J SutoK Sekikawa

Abstract

KK mouse is known as a polygenic model for noninsulin-dependent diabetes mellitus with moderate obesity. To identify the quantitative trait loci (QTLs) responsible for the body weight in KK, linkage analysis with 97 microsatellite markers was carried out into 192 F2 progeny, comprising 93 mice with a/a genotype at agouti locus and 99 mice with A(y)/a genotype, of a cross between C57BL/6J female and KK-A(y) (A(y) congenic) male, thereby the influence of A(y) allele on the quantitative regulation of body weight was also examined. In F2 a/a mice, we identified a QTL on Chromosome (Chr) 4, and two loci with suggestive linkage on Chrs 15 and 18. In F2 A(y)/a mice, a QTL was identified on Chr 6, and two loci with suggestive linkage were identified on Chrs 4 and 16. That the QTL on Chr 4 was held in common between F2 a/a and F2 A(y)/a progenies implies that this locus may be a primary component regulating body weight in KK and KK-A(y). These results suggest that the body weight in KK is controlled by multiple genes, and the different combination of loci is involved in the presence of A(y) allele. The QTL on Chr 6 seemed to determine the body weight by controlling fat deposition, because the linkage was identified on body weight and ad...Continue Reading

Citations

Jan 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ioannis M StylianouGary A Churchill
Dec 11, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jun-Ichi Suto
Jan 1, 2009·Molecular and Cellular Biochemistry·Elizabeth P NewberryNicholas O Davidson
Oct 26, 2011·The British Journal of Nutrition·Wendy Foulds MathesDaniel Pomp
Mar 24, 2011·American Journal of Physiology. Endocrinology and Metabolism·Wendy Foulds MathesDaniel Pomp
May 1, 2006·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Jun-Ichi Suto
Aug 23, 2001·Experimental Animals·R V AnunciadoT Namikawa
Apr 19, 2005·Obesity Research·Louis PérusseClaude Bouchard
Mar 27, 2004·Obesity Research·Eric E SnyderClaude Bouchard
Mar 14, 2003·Obesity Research·Yvon C ChagnonClaude Bouchard
Jul 12, 2003·Obesity Research·Shumin Zhang, Howard K Gershenfeld
Jun 3, 2006·Obesity·Tuomo RankinenClaude Bouchard
Oct 9, 2004·The Journal of Veterinary Medical Science·Jun-Ichi Suto, Kenji Sekikawa
Mar 11, 2000·Obesity Research·Y C ChagnonC Bouchard
Mar 12, 2002·Obesity Research·Tuomo RankinenClaude Bouchard
Apr 24, 2001·Obesity Research·L PérusseC Bouchard
Apr 15, 2000·Nature·G S BarshS O'Rahilly
Sep 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shigeru TakeshitaMitsuo Itakura
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Matthew D BreyerUNKNOWN AMDCC
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J Suto, K Sekikawa
Oct 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S WuschkeH Al-Hasani
Jul 17, 2008·Physiological Genomics·Natsuko HadaFumihiko Horio
Jul 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S RogersRobert J D'Amato
Oct 19, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jun-Ichi Suto, Misaki Kojima
Feb 27, 2015·The Journal of Veterinary Medical Science·Kunio Satou, Jun-ichi Suto
Dec 22, 1999·Biochemical and Biophysical Research Communications·Y KagawaH Endo
May 14, 1999·Drug Discovery Today·K J Moore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Eri NishiharaFumihiro Sugiyama
Mammalian Genome : Official Journal of the International Mammalian Genome Society
J SutoK Sekikawa
Mammalian Genome : Official Journal of the International Mammalian Genome Society
B A TaylorS J Phillips
© 2022 Meta ULC. All rights reserved