Genetics of Resistant Hypertension: the Missing Heritability and Opportunities

Current Hypertension Reports
Samantha K TeixeiraJose E Krieger

Abstract

Blood pressure regulation in humans has long been known to be a genetically determined trait. The identification of causal genetic modulators for this trait has been unfulfilling at the least. Despite the recent advances of genome-wide genetic studies, loci associated with hypertension or blood pressure still explain a very low percentage of the overall variation of blood pressure in the general population. This has precluded the translation of discoveries in the genetics of human hypertension to clinical use. Here, we propose the combined use of resistant hypertension as a trait for mapping genetic determinants in humans and the integration of new large-scale technologies to approach in model systems the multidimensional nature of the problem. New large-scale efforts in the genetic and genomic arenas are paving the way for an increased and granular understanding of genetic determinants of hypertension. New technologies for whole genome sequence and large-scale forward genetic screens can help prioritize gene and gene-pathways for downstream characterization and large-scale population studies, and guided pharmacological design can be used to drive discoveries to the translational application through better risk stratification a...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Apr 26, 2000·Genome Research·M StollH J Jacob
Mar 10, 2001·Cell·R P LiftonD S Geller
May 11, 2005·American Journal of Hypertension·Jay P GargUNKNOWN RUSH University Hypertension Service
Oct 13, 2006·Nature Reviews. Genetics·Allen W Cowley
Apr 24, 2008·BMC Medical Genetics·Camila M de OliveiraJosé E Krieger
May 6, 2008·Lancet·Carlene M M LawesUNKNOWN International Society of Hypertension
Jul 1, 2008·Nature Genetics·Michal PravenecTheodore W Kurtz
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Feb 11, 2011·Nature·Eric S Lander
Sep 13, 2011·Nature·UNKNOWN International Consortium for Blood Pressure Genome-Wide Association StudiesToby Johnson
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Or ZukEric S Lander
Mar 2, 2012·Circulation·Stacie L DaughertyP Michael Ho
Aug 8, 2012·Hypertension·Michael J FlisterHoward J Jacob
Nov 22, 2012·BMJ : British Medical Journal·Aung MyatBryan Williams
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kathirvel GopalakrishnanBina Joe
Jan 7, 2014·Journal of the American Society of Hypertension : JASH·Vanessa FontanaHeitor Moreno
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Nov 12, 2014·Journal of the American Heart Association·Vanessa FontanaRhonda M Cooper-DeHoff
Jan 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tao WangBruce Beutler
Feb 20, 2015·Nature·UNKNOWN Roadmap Epigenomics ConsortiumManolis Kellis
Jun 7, 2015·American Journal of Hypertension·Alessandra Mileni Versuti RitterHeitor Moreno
Jun 28, 2016·American Journal of Human Genetics·Huwenbo ShiBogdan Pasaniuc
Apr 13, 2017·European Journal of Human Genetics : EJHG·Ilja M NolteHarold Snieder
Jun 18, 2017·Cell·Evan A BoyleJonathan K Pritchard
Jul 8, 2017·American Journal of Human Genetics·Peter M VisscherJian Yang
Oct 13, 2017·Nature·UNKNOWN GTEx ConsortiumStephen B Montgomery
Nov 22, 2017·JAMA : the Journal of the American Medical Association·Adam S Cifu, Andrew M Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Clinical Pharmacology
Ruth J F Loos
The Psychiatric Clinics of North America
Dimitrios Avramopoulos
© 2022 Meta ULC. All rights reserved