Genetics of restless legs syndrome

Sleep Medicine Reviews
Juliane Winkelmann, Luigi Ferini-Strambi

Abstract

Several studies on restless legs syndrome (RLS) have suggested a substantial genetic contribution in the etiology of this sleep disorder. Clinical surveys of idiopathic RLS patients have shown that 40-90% report a positive family history. The clinical features have been compared between familial and sporadic cases and the only difference found was a younger age-at-onset in familial RLS. Despite several reports suggesting a genetic contribution to the etiology of idiopathic RLS, few molecular genetic studies have been carried out attempting to identify genes that can predispose to this disorder. In particular, genes encoding for the GABA A receptor subunits, the gene for the alpha1 subunit of the glycine receptor, and genes involved in dopaminergic transmission and metabolism have been analyzed, however no significant findings have been reported. Genomewide linkage analysis studies using microsatellite markers have identified three loci for RLS: on chromosome 12q, on chromosome 14q and on chromosome 9p. It is important to investigate whether further RLS families show linkage to one of these loci to discuss the contribution of these loci and to provide a prerequisite of a mutational screening and identification of the RLS genes.

References

Nov 1, 1990·Archives of Neurology·A S WaltersA Lazzarini
Dec 1, 1996·Neurology·W Ondo, J Jankovic
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirP Lespérance
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A LazzariniW G Johnson
Mar 13, 2001·European Neurology·C L BassettiC W Hess
May 24, 2003·Brain : a Journal of Neurology·Maria Teresa BonatiGiorgio Casari
Jan 28, 2004·Archives of Internal Medicine·Klaus BergerChristof Kessler
Jun 3, 2004·Annals of Neurology·Anastasia LevchenkoGuy A Rouleau
Aug 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Juliane WinkelmannBertram Muller-Myhsok

❮ Previous
Next ❯

Citations

May 4, 2011·Journal of Neurology·Shiho SuzukiKoichi Hirata
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·Shilpa Chitnis
Mar 4, 2008·Expert Opinion on Pharmacotherapy·Richard K Bogan
Oct 20, 2009·Child and Adolescent Psychiatric Clinics of North America·Elana R Bloomfield, Jess P Shatkin
Jun 15, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Alexander UnrathJan Kassubek
Dec 3, 2014·Sleep Medicine Reviews·Mariusz SieminskiMarkku Partinen
Jun 3, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jananie BalendranAlec Welsh
Jun 21, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Juan C Gómez-EstebanAmaia Ugarte
Sep 25, 2007·Cephalalgia : an International Journal of Headache·A M RhodeS Evers
Nov 28, 2012·Journal of Health Psychology·Maria José V VarelaGilmar F do Prado
Jun 20, 2008·Journal of Psychopharmacology·Seung-Gul KangLeen Kim
Dec 16, 2006·Nephrology News & Issues
Apr 1, 2008·The Diabetes Educator·Norma G Cuellar, Sarah J Ratcliffe
Apr 4, 2018·International Journal of Colorectal Disease·Janek BeckerJochen Maul
Jun 28, 2007·Nature Clinical Practice. Neurology·Claudia Trenkwalder
May 31, 2020·Multiple Sclerosis and Related Disorders·Serhan SevimDerya Kaya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Juliane WinkelmannBertram Müller-Myhsok
Sleep Medicine
Luigi Ferini-StrambiGiorgio Casari
Movement Disorders : Official Journal of the Movement Disorder Society
Susanna AdelChristine Klein
© 2022 Meta ULC. All rights reserved