Genetics of scapula and pelvis development: An evolutionary perspective

Current Topics in Developmental Biology
Mariel YoungTerence D Capellini

Abstract

In tetrapods, the scapular and pelvic girdles perform the important function of anchoring the limbs to the trunk of the body and facilitating the movement of each appendage. This shared function, however, is one of relatively few similarities between the scapula and pelvis, which have significantly different morphologies, evolutionary histories, embryonic origins, and underlying genetic pathways. The scapula evolved in jawless fish prior to the pelvis, and its embryonic development is unique among bones in that it is derived from multiple progenitor cell populations, including the dermomyotome, somatopleure, and neural crest. Conversely, the pelvis evolved several million years later in jawed fish, and it develops from an embryonic somatopleuric cell population. The genetic networks controlling the formation of the pelvis and scapula also share similarities and differences, with a number of genes shaping only one or the other, while other gene products such as PBX transcription factors act as hierarchical developmental regulators of both girdle structures. Here, we provide a detailed review of the cellular processes and genetic networks underlying pelvis and scapula formation in tetrapods, while also highlighting unanswered que...Continue Reading

Citations

Feb 6, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Charles C RosemanJames M Cheverud
Sep 5, 2019·Biomimetics·Fabio Galbusera, Tito Bassani
Mar 3, 2019·Genes & Development·Licia SelleriElisabetta Ferretti
Dec 15, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gabriel L GaleaPhilippa Francis-West
Dec 18, 2020·Frontiers in Genetics·Jian Ming Khor, Charles A Ettensohn
Jun 7, 2021·Forensic Science International : Synergy·Louise K CorronJaroslav Brůžek

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