Genetics of sudden cardiac death in children and young athletes

Cardiology in the Young
Georgia Sarquella-BrugadaRamon Brugada

Abstract

Sudden cardiac death is a rare but socially devastating event. The most common causes of sudden cardiac death are congenital electrical disorders and structural heart diseases. The majority of these diseases have an incomplete penetrance and variable expression; therefore, patients may be unaware of their illness. In several cases, physical activity can be the trigger for sudden cardiac death as first symptom. Our purpose is to review the causes of sudden cardiac death in sportive children and young adults and its genetic background. Symptomatic individuals often receive an implantable cardioverter-defibrillator, the preventive treatment for sudden cardiac death in most of cases due to channelopathies, which can become a challenging option in young and active patients. The identification of one of these diseases in asymptomatic patients has similarly a great impact on their everyday life, especially on their ability to undertake competitive physical activities, and the requirement of prophylactic treatment. We review main causes of sudden cardiac death in relation to its genetics and diagnostic work-up

References

Oct 15, 2014·Current Opinion in Pediatrics·Shashank P BehereSteven N Weindling
Sep 23, 2016·International Journal of Legal Medicine·Antonio OlivaRamon Brugada
Feb 18, 2014·International Journal of Legal Medicine·Oscar CampuzanoRamon Brugada
Aug 20, 2017·Archives of Disease in Childhood·Shuenn-Nan ChiuMei-Hwan Wu

Citations

Jan 1, 1990·Journal of the American College of Cardiology·P S DouglasN Reichek
May 1, 1984·The American Journal of Cardiology·G J BaladyT J Ryan
Apr 18, 1996·The New England Journal of Medicine·R R Liberthson
Jul 12, 1997·Lancet·B J Maron
Jun 26, 1998·Clinical Science·H L ThomsonMichael P Frenneaux
Dec 19, 1998·Journal of the American College of Cardiology·B J MaronD Aeppli
Feb 15, 2001·Cardiology·Ihor GussakP Bjerregaard
Mar 12, 2003·Journal of the American College of Cardiology·Matthew R G TaylorFamilial Dilated Cardiomyopathy Registry Research Group
Aug 20, 2003·Circulation·Fiorenzo GaitaMartin Borggrefe
Sep 12, 2003·The New England Journal of Medicine·B J Maron
Dec 10, 2003·Journal of the American College of Cardiology·Domenico CorradoGaetano Thiene
Dec 17, 2003·Circulation·Ramon BrugadaCharles Antzelevitch
Feb 11, 2004·Circulation·Gunther WeitzChristoph Dodt
Aug 28, 2004·Pediatric Clinics of North America·B J Maron
Aug 28, 2004·Pediatric Clinics of North America·Rima S BaderDavid J Sahn
Oct 7, 2004·Circulation·William P McNairFamilial Cardiomyopathy Registry Research Group
Nov 20, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jop H van BerloYigal M Pinto
Apr 20, 2005·Journal of the American College of Cardiology·Douglas P ZipesGeorge Van Hare
May 19, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchArthur A M Wilde
Jul 30, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J-M DupuisG Bellon
Sep 16, 2005·Heart·Arthur A M Wilde, Connie R Bezzina
Sep 29, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David J TesterMichael J Ackerman
Jul 5, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David J TesterMichael J Ackerman
Oct 5, 2006·JAMA : the Journal of the American Medical Association·Domenico CorradoGaetano Thiene
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Jeffrey A TowbinSteven E Lipshultz
Dec 5, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Antonio PellicciaSilvia G Priori
Apr 4, 2007·Circulation·Vincent ProbstArthur A M Wilde
Apr 7, 2007·Current Opinion in Cardiology·J Martijn BosMichael J Ackerman
Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Tamaki HayashiShigeyuki Echigo
Nov 16, 2007·Orphanet Journal of Rare Diseases·Gaetano ThieneCristina Basso
Apr 10, 2008·Archives of Cardiovascular Diseases·I DenjoyA Leenhardt
May 20, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jonathan A DreznerLinette Derminer

Related Concepts

Work-up
Asymptomatic Diseases
Exercise, Isometric
Channelopathies
Sudden Cardiac Arrest
Cardiomyopathies
Electrical Injuries
Drugs used in migraine prophylaxis
Implantable Defibrillator
Heart Diseases

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Current Opinion in Cardiology
Raffaella Lombardi
The New England Journal of Medicine
Alan KadishDefibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
Critical Care Nursing Quarterly
Vicki L Zeigler, Linda Payne
The Journal of Tehran Heart Center
Mohammad AlastiMohammad Hossein Jadbabaei
The New England Journal of Medicine
Gust H BardySudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
© 2020 Meta ULC. All rights reserved