Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects

Genes and Immunity
Helena HavelkováMarie Lipoldová

Abstract

Symptoms of human leishmaniasis range from subclinical to extensive systemic disease with splenomegaly, hepatomegaly, skin lesions, anemia and hyperglobulinemia, but the basis of this variation is unknown. Association of progression of the disease with Th2 lymphocyte response was reported in mice but not in humans. As most genetic studies in Leishmania major (L. major)-infected mice were restricted to skin lesions, we analyzed the symptomatology of leishmaniasis in mice by monitoring skin lesions, hepatomegaly, splenomegaly and seven immunological parameters. We detected and mapped 17 Leishmania major response (Lmr) gene loci that control the symptoms of infection. Surprisingly, the individual Lmr loci control 13 different combinations of pathological and immunological symptoms. Seven loci control both pathological and immunological parameters, 10 influence immunological parameters only. Moreover, the genetics of clinical symptoms is also very heterogeneous: loci Lmr13 and Lmr4 determine skin lesions only, Lmr5 and Lmr10 skin lesions and splenomegaly, Lmr14 and Lmr3 splenomegaly and hepatomegaly, Lmr3 (weakly) skin lesions, and Lmr15 hepatomegaly only. Only two immunological parameters, IgE and interferon-gamma serum levels, co...Continue Reading

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Citations

Jul 3, 2013·Immunology and Cell Biology·Amitabha ChaudhuriAvi Ashkenazi
Jun 15, 2011·PLoS Neglected Tropical Diseases·Matyáš SímaMarie Lipoldová
Jul 23, 2013·PLoS Neglected Tropical Diseases·Yahya SohrabiMarie Lipoldová
Jun 3, 2011·Genes and Immunity·L CastellucciJ M Blackwell
Jul 21, 2009·Trends in Parasitology·Anuratha SakthianandeswarenEmanuela Handman
Nov 1, 2008·The American Journal of Pathology·Maren von Köckritz-BlickwedeEva Medina
Oct 15, 2013·Biological Reviews of the Cambridge Philosophical Society·Elena S GusarevaMarie Lipoldová
Sep 6, 2011·Journal of Microbiological Methods·Igor GrekovMarie Lipoldová
Sep 22, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A L BañulsM Hide
Mar 18, 2006·Nature Reviews. Genetics·Marie Lipoldová, Peter Demant
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick M SmithMiguel J Stadecker
Feb 23, 2018·Frontiers in Immunology·Yahya SohrabiMarie Lipoldová
Nov 30, 2016·Biology of Sex Differences·Martina SlapničkováMarie Lipoldová
Oct 17, 2020·Cytokine·Imtissal Krayem, Marie Lipoldová

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