PMID: 9545495May 8, 1998Paper

Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on chromosomes 9 and 16

Mammalian Genome : Official Journal of the International Mammalian Genome Society
N MoriP Demant

Abstract

Apoptosis, a mechanism for removal of genetically damaged cells and for maintenance of desired size of cell populations, has been implicated in tumor development. Previously, we defined polymorphic loci for susceptibility to apoptosis of thymocytes Rapop1, Rapop2, and Rapop3 on mouse Chromosomes 16, 9, and 3, respectively, using recombinant congenic CcS/Dem strains, each of which contains a random set of 12.5% STS/A genome in the genetic background of BALB/cHeA. The STS/A alleles at these loci confer lower susceptibility to radiation-induced apoptosis of thymocytes than the BALB/cHeA. In the present study, we tested susceptibility of colon crypt cells to radiation-induced apoptosis. In contrast to apoptosis in thymus, the STS/A mice were more susceptible to apoptosis in colon than the BALB/cHeA. Among the CcS/Dem strains, CcS-4, CcS-7, and CcS-16 were more susceptible to apoptosis in colon than the BALB/cHeA; in thymus, the CcS-7 mice are less susceptible, and the CcS-4 and CcS-16 are not different from the BALB/cHeA. Thus, individual CcS/Dem strains showed different apoptosis susceptibility in the two organs. Analysis of (CcS-7 x BALB/cHeA)F2 hybrids revealed linkage of susceptibility to radiation-induced apoptosis of colon cr...Continue Reading

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Citations

Jan 12, 2005·The Journal of Pathology·Philip J CoatesEric G Wright
Dec 1, 1995·Trends in Genetics : TIG·W N Frankel
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Annette SchmitzGilles Thomas
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Dec 16, 2020·International Journal of Molecular Sciences·Binod PrasadMarcus Krüger

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis