Genetics of systemic sclerosis: recent advances

Current Opinion in Rheumatology
Paula S RamosCarol A Feghali-Bostwick

Abstract

Large-scale and follow-up genetic association studies in systemic sclerosis (SSc) have implicated over 40 regions in disease risk, 15 of which with robust associations. Nevertheless, the causal variants and the functional mechanisms underlying the genetic associations remain elusive, and the reasons for the higher disease burden in African Americans unknown. Incorporating tools from diverse fields is beginning to unveil the role of genetic diversity and regulatory variation in SSc susceptibility. This review will summarize recent advances in SSc genetics, including autoimmune disease overlap, evidence of natural selection, and current progress towards the dissection of the functional role of associated risk variants. In the past year, multiple large-scale studies reported novel strong and suggestive SSc associations. These results, coupled with the regions shared with other autoimmune diseases, emphasize the role of dysregulation of immune pathways as a key causative factor in SSc pathogenesis. Strong evidence implicates natural selection as a mechanism contributing to the maintenance of some of these SSc alleles in the population. Studies integrating genomic, transcriptomic, and epigenomic datasets in specific cell types to id...Continue Reading

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Citations

Dec 6, 2016·Clinical Genetics·Xiaoxia ZuoHonglin Zhu
Feb 25, 2018·European Journal of Human Genetics : EJHG·Carmel J W Stock, Elisabetta A Renzoni
Oct 6, 2018·European Journal of Clinical Investigation·Jonas BystromRizgar A Mageed
Nov 30, 2018·Frontiers in Immunology·Arjan van CaamPeter van der Kraan
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Pravitt GourhElaine F Remmers
Oct 18, 2019·International Journal of Rheumatic Diseases·Lixian ZhongLin Wu
Mar 30, 2021·Frontiers in Immunology·Meifang LiuCai Zhang
Jul 16, 2019·La Revue de médecine interne·K DidierA Servettaz

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Methods Mentioned

BETA
genotyping
biopsies
dissection

Software Mentioned

Immunochip

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